Persistent ER stress causes GPI anchor deficit to convert a GPI-anchored prion protein into pro-PrP via the ATF6–miR449c-5p–PIGV axis

Endoplasmic reticulum (ER) stress and unfolded protein response are cells’ survival strategies to thwart disruption of proteostasis. Tumor cells are continuously being challenged by ER stress. The prion protein, PrP, normally a glycosylphosphatidylinositol (GPI)-anchored protein exists as a pro-PrP...

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Detalles Bibliográficos
Autores principales: Li, JingFeng, Li, SaSa, Yu, ShuPei, Yang, Jie, Ke, JingRu, Li, Huan, Chen, Heng, Lu, MingJian, Sy, Man-Sun, Gao, ZhenXing, Li, Chaoyang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10388210/
https://www.ncbi.nlm.nih.gov/pubmed/37390992
http://dx.doi.org/10.1016/j.jbc.2023.104982

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