Comprehensive molecular and clinical characterization of NUP98 fusions in pediatric acute myeloid leukemia

NUP98 fusions comprise a family of rare recurrent alterations in AML, associated with adverse outcomes. In order to define the underlying biology and clinical implications of this family of fusions, we performed comprehensive transcriptome, epigenome, and immunophenotypic profiling of 2,235 children...

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Detalles Bibliográficos
Autores principales: Bertrums, Eline J. M., Smith, Jenny L., Harmon, Lauren, Ries, Rhonda E., Wang, Yi-Cheng J., Alonzo, Todd A., Menssen, Andrew J., Chisholm, Karen M., Leonti, Amanda R., Tarlock, Katherine, Ostronoff, Fabiana, Pogosova-Agadjanyan, Era L., Kaspers, Gertjan J. L., Hasle, Henrik, Dworzak, Michael, Walter, Christiane, Mühlegger, Nora, Morerio, Cristina, Pardo, Laura, Hirsch, Betsy, Raimondi, Susana, Cooper, Todd M., Aplenc, Richard, Gamis, Alan S., Kolb, Edward A., Farrar, Jason E., Stirewalt, Derek, Ma, Xiaotu, Shaw, Tim I., Furlan, Scott N., Brodersen, Lisa Eidenschink, Loken, Michael R., van den Heuvel-Eibrink, Marry M., Zwaan, C. Michel, Triche, Timothy J., Goemans, Bianca F., Meshinchi, Soheil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Fondazione Ferrata Storti 2023
Materias:
Article - Acute Myeloid Leukemia
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10388277/
https://www.ncbi.nlm.nih.gov/pubmed/36815378
http://dx.doi.org/10.3324/haematol.2022.281653

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