Innovative Strategy toward Mutant CFTR Rescue in Cystic Fibrosis: Design and Synthesis of Thiadiazole Inhibitors of the E3 Ligase RNF5

[Image: see text] In cystic fibrosis (CF), deletion of phenylalanine 508 (F508del) in the CF transmembrane conductance regulator (CFTR) is associated to misfolding and defective gating of the mutant channel. One of the most promising CF drug targets is the ubiquitin ligase RNF5, which promotes F508d...

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Detalles Bibliográficos
Autores principales: Brusa, Irene, Sondo, Elvira, Pesce, Emanuela, Tomati, Valeria, Gioia, Dario, Falchi, Federico, Balboni, Beatrice, Ortega Martínez, Jose Antonio, Veronesi, Marina, Romeo, Elisa, Margaroli, Natasha, Recanatini, Maurizio, Girotto, Stefania, Pedemonte, Nicoletta, Roberti, Marinella, Cavalli, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10388311/
https://www.ncbi.nlm.nih.gov/pubmed/37440686
http://dx.doi.org/10.1021/acs.jmedchem.3c00608

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10388311/
https://www.ncbi.nlm.nih.gov/pubmed/37440686
http://dx.doi.org/10.1021/acs.jmedchem.3c00608

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