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Innovative Strategy toward Mutant CFTR Rescue in Cystic Fibrosis: Design and Synthesis of Thiadiazole Inhibitors of the E3 Ligase RNF5
[Image: see text] In cystic fibrosis (CF), deletion of phenylalanine 508 (F508del) in the CF transmembrane conductance regulator (CFTR) is associated to misfolding and defective gating of the mutant channel. One of the most promising CF drug targets is the ubiquitin ligase RNF5, which promotes F508d...
Autores principales: | Brusa, Irene, Sondo, Elvira, Pesce, Emanuela, Tomati, Valeria, Gioia, Dario, Falchi, Federico, Balboni, Beatrice, Ortega Martínez, Jose Antonio, Veronesi, Marina, Romeo, Elisa, Margaroli, Natasha, Recanatini, Maurizio, Girotto, Stefania, Pedemonte, Nicoletta, Roberti, Marinella, Cavalli, Andrea |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10388311/ https://www.ncbi.nlm.nih.gov/pubmed/37440686 http://dx.doi.org/10.1021/acs.jmedchem.3c00608 |
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