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Heterogeneous-Driven Glutathione Oxidation: Defining the Catalytic Role of Chalcopyrite Nanoparticles

[Image: see text] Transition-metal nanocatalysis represents a novel alternative currently experiencing flourishing progress to tackle the tumor microenvironment (TME) in cancer therapy. These nanomaterials aim at attacking tumor cells using the intrinsic selectivity of inorganic catalysts. In additi...

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Autores principales: Sanchez-Uriel, Leticia, Bonet-Aleta, Javier, Ibarra, Alfonso, Hueso, Jose L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10388351/
https://www.ncbi.nlm.nih.gov/pubmed/37529663
http://dx.doi.org/10.1021/acs.jpcc.3c00987
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author Sanchez-Uriel, Leticia
Bonet-Aleta, Javier
Ibarra, Alfonso
Hueso, Jose L.
author_facet Sanchez-Uriel, Leticia
Bonet-Aleta, Javier
Ibarra, Alfonso
Hueso, Jose L.
author_sort Sanchez-Uriel, Leticia
collection PubMed
description [Image: see text] Transition-metal nanocatalysis represents a novel alternative currently experiencing flourishing progress to tackle the tumor microenvironment (TME) in cancer therapy. These nanomaterials aim at attacking tumor cells using the intrinsic selectivity of inorganic catalysts. In addition, special attention to tune and control the release of these transition metals is also required. Understanding the chemical reactions behind the catalytic action of the transition-metal nanocatalysts and preventing potential undesired side reactions caused by acute cytotoxicity of the released ionic species represent another important field of research. Specifically, copper-based oxides may suffer from acute leaching that potentially may induce toxicity not only to target cancer cells but also to nearby cells and tissues. In this work, we propose the synthesis of chalcopyrite (CuFeS(2)) nanostructures capable of triggering two key reactions for an effective chemodynamic therapy (CDT) in the heterogeneous phase: (i) glutathione (GSH) oxidation and (ii) oxidation of organic substrates using H(2)O(2), with negligible leaching of metals under TME-like conditions. This represents an appealing alternative toward the development of safer copper–iron-based nanocatalytic materials with an active catalytic response without incurring leaching side phenomena.
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spelling pubmed-103883512023-08-01 Heterogeneous-Driven Glutathione Oxidation: Defining the Catalytic Role of Chalcopyrite Nanoparticles Sanchez-Uriel, Leticia Bonet-Aleta, Javier Ibarra, Alfonso Hueso, Jose L. J Phys Chem C Nanomater Interfaces [Image: see text] Transition-metal nanocatalysis represents a novel alternative currently experiencing flourishing progress to tackle the tumor microenvironment (TME) in cancer therapy. These nanomaterials aim at attacking tumor cells using the intrinsic selectivity of inorganic catalysts. In addition, special attention to tune and control the release of these transition metals is also required. Understanding the chemical reactions behind the catalytic action of the transition-metal nanocatalysts and preventing potential undesired side reactions caused by acute cytotoxicity of the released ionic species represent another important field of research. Specifically, copper-based oxides may suffer from acute leaching that potentially may induce toxicity not only to target cancer cells but also to nearby cells and tissues. In this work, we propose the synthesis of chalcopyrite (CuFeS(2)) nanostructures capable of triggering two key reactions for an effective chemodynamic therapy (CDT) in the heterogeneous phase: (i) glutathione (GSH) oxidation and (ii) oxidation of organic substrates using H(2)O(2), with negligible leaching of metals under TME-like conditions. This represents an appealing alternative toward the development of safer copper–iron-based nanocatalytic materials with an active catalytic response without incurring leaching side phenomena. American Chemical Society 2023-07-12 /pmc/articles/PMC10388351/ /pubmed/37529663 http://dx.doi.org/10.1021/acs.jpcc.3c00987 Text en © 2023 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Sanchez-Uriel, Leticia
Bonet-Aleta, Javier
Ibarra, Alfonso
Hueso, Jose L.
Heterogeneous-Driven Glutathione Oxidation: Defining the Catalytic Role of Chalcopyrite Nanoparticles
title Heterogeneous-Driven Glutathione Oxidation: Defining the Catalytic Role of Chalcopyrite Nanoparticles
title_full Heterogeneous-Driven Glutathione Oxidation: Defining the Catalytic Role of Chalcopyrite Nanoparticles
title_fullStr Heterogeneous-Driven Glutathione Oxidation: Defining the Catalytic Role of Chalcopyrite Nanoparticles
title_full_unstemmed Heterogeneous-Driven Glutathione Oxidation: Defining the Catalytic Role of Chalcopyrite Nanoparticles
title_short Heterogeneous-Driven Glutathione Oxidation: Defining the Catalytic Role of Chalcopyrite Nanoparticles
title_sort heterogeneous-driven glutathione oxidation: defining the catalytic role of chalcopyrite nanoparticles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10388351/
https://www.ncbi.nlm.nih.gov/pubmed/37529663
http://dx.doi.org/10.1021/acs.jpcc.3c00987
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