Novel 1,4-Dihydropyridines as Specific Binders and Activators of SIRT3 Impair Cell Viability and Clonogenicity and Downregulate Hypoxia-Induced Targets in Cancer Cells

[Image: see text] The mitochondrial SIRT3 modulates several biological pathways such as cancer, metabolism, and hypoxia-related diseases. Recently, we discovered new 1,4-dihydropyridines, compounds 2 and 3, the latter being a SIRT3-specific activator. In the present work, a novel 2- and 3-related sm...

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Detalles Bibliográficos
Autores principales: Zwergel, Clemens, Aventaggiato, Michele, Garbo, Sabrina, Di Bello, Elisabetta, Fassari, Bruno, Noce, Beatrice, Castiello, Carola, Lambona, Chiara, Barreca, Federica, Rotili, Dante, Fioravanti, Rossella, Schmalz, Thomas, Weyand, Michael, Niedermeier, Amelie, Tripodi, Marco, Colotti, Gianni, Steegborn, Clemens, Battistelli, Cecilia, Tafani, Marco, Valente, Sergio, Mai, Antonello
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10388363/
https://www.ncbi.nlm.nih.gov/pubmed/37439550
http://dx.doi.org/10.1021/acs.jmedchem.3c00337

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