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Novel diagnostic markers for periprosthetic joint infection: a systematic review
BACKGROUND: Identifying novel biomarkers that are both specific and sensitive to periprosthetic joint infection (PJI) has the potential to improve diagnostic accuracy and ultimately enhance patient outcomes. Therefore, the aim of this systematic review is to identify and evaluate the effectiveness o...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10388554/ https://www.ncbi.nlm.nih.gov/pubmed/37529352 http://dx.doi.org/10.3389/fcimb.2023.1210345 |
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author | Schindler, Melanie Walter, Nike Maderbacher, Guenther Sigmund, Irene K. Alt, Volker Rupp, Markus |
author_facet | Schindler, Melanie Walter, Nike Maderbacher, Guenther Sigmund, Irene K. Alt, Volker Rupp, Markus |
author_sort | Schindler, Melanie |
collection | PubMed |
description | BACKGROUND: Identifying novel biomarkers that are both specific and sensitive to periprosthetic joint infection (PJI) has the potential to improve diagnostic accuracy and ultimately enhance patient outcomes. Therefore, the aim of this systematic review is to identify and evaluate the effectiveness of novel biomarkers for the diagnosis of PJI. METHODS: We searched the MEDLINE, EMBASE, PubMed, and Cochrane Library databases from January 1, 2018, to September 30, 2022, using the search terms “periprosthetic joint infection,” “prosthetic joint infection,” or “periprosthetic infection” as the diagnosis of interest and the target index, combined with the term “marker.” We excluded articles that mentioned established biomarkers such as CRP, ESR, Interleukin 6, Alpha defensin, PCT (procalcitonin), and LC (leucocyte cell count). We used the MSIS, ICM, or EBJS criteria for PJI as the reference standard during quality assessment. RESULTS: We collected 19 studies that analyzed fourteen different novel biomarkers. Proteins were the most commonly analyzed biomarkers (nine studies), followed by molecules (three studies), exosomes (two studies), DNA (two studies), interleukins (one study), and lysosomes (one study). Calprotectin was a frequently analyzed and promising marker. In the scenario where the threshold was set at ≥50-mg/mL, the calprotectin point-of-care (POC) performance showed a high sensitivity of 98.1% and a specificity of 95.7%. CONCLUSION: None of the analyzed biomarkers demonstrated outstanding performance compared to the established parameters used for standardized treatment based on established PJI definitions. Further studies are needed to determine the benefit and usefulness of implementing new biomarkers in diagnostic PJI settings. |
format | Online Article Text |
id | pubmed-10388554 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-103885542023-08-01 Novel diagnostic markers for periprosthetic joint infection: a systematic review Schindler, Melanie Walter, Nike Maderbacher, Guenther Sigmund, Irene K. Alt, Volker Rupp, Markus Front Cell Infect Microbiol Cellular and Infection Microbiology BACKGROUND: Identifying novel biomarkers that are both specific and sensitive to periprosthetic joint infection (PJI) has the potential to improve diagnostic accuracy and ultimately enhance patient outcomes. Therefore, the aim of this systematic review is to identify and evaluate the effectiveness of novel biomarkers for the diagnosis of PJI. METHODS: We searched the MEDLINE, EMBASE, PubMed, and Cochrane Library databases from January 1, 2018, to September 30, 2022, using the search terms “periprosthetic joint infection,” “prosthetic joint infection,” or “periprosthetic infection” as the diagnosis of interest and the target index, combined with the term “marker.” We excluded articles that mentioned established biomarkers such as CRP, ESR, Interleukin 6, Alpha defensin, PCT (procalcitonin), and LC (leucocyte cell count). We used the MSIS, ICM, or EBJS criteria for PJI as the reference standard during quality assessment. RESULTS: We collected 19 studies that analyzed fourteen different novel biomarkers. Proteins were the most commonly analyzed biomarkers (nine studies), followed by molecules (three studies), exosomes (two studies), DNA (two studies), interleukins (one study), and lysosomes (one study). Calprotectin was a frequently analyzed and promising marker. In the scenario where the threshold was set at ≥50-mg/mL, the calprotectin point-of-care (POC) performance showed a high sensitivity of 98.1% and a specificity of 95.7%. CONCLUSION: None of the analyzed biomarkers demonstrated outstanding performance compared to the established parameters used for standardized treatment based on established PJI definitions. Further studies are needed to determine the benefit and usefulness of implementing new biomarkers in diagnostic PJI settings. Frontiers Media S.A. 2023-07-17 /pmc/articles/PMC10388554/ /pubmed/37529352 http://dx.doi.org/10.3389/fcimb.2023.1210345 Text en Copyright © 2023 Schindler, Walter, Maderbacher, Sigmund, Alt and Rupp https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cellular and Infection Microbiology Schindler, Melanie Walter, Nike Maderbacher, Guenther Sigmund, Irene K. Alt, Volker Rupp, Markus Novel diagnostic markers for periprosthetic joint infection: a systematic review |
title | Novel diagnostic markers for periprosthetic joint infection: a systematic review |
title_full | Novel diagnostic markers for periprosthetic joint infection: a systematic review |
title_fullStr | Novel diagnostic markers for periprosthetic joint infection: a systematic review |
title_full_unstemmed | Novel diagnostic markers for periprosthetic joint infection: a systematic review |
title_short | Novel diagnostic markers for periprosthetic joint infection: a systematic review |
title_sort | novel diagnostic markers for periprosthetic joint infection: a systematic review |
topic | Cellular and Infection Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10388554/ https://www.ncbi.nlm.nih.gov/pubmed/37529352 http://dx.doi.org/10.3389/fcimb.2023.1210345 |
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