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The Lucerne Toolbox 2 to optimise axillary management for early breast cancer: a multidisciplinary expert consensus
Clinical axillary lymph node management in early breast cancer has evolved from being merely an aspect of surgical management and now includes the entire multidisciplinary team. The second edition of the “Lucerne Toolbox”, a multidisciplinary consortium of European cancer societies and patient repre...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10388578/ https://www.ncbi.nlm.nih.gov/pubmed/37528842 http://dx.doi.org/10.1016/j.eclinm.2023.102085 |
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author | Kaidar-Person, Orit Pfob, André Gentilini, Oreste Davide Borisch, Bettina Bosch, Ana Cardoso, Maria João Curigliano, Giuseppe De Boniface, Jana Denkert, Carsten Hauser, Nik Heil, Jörg Knauer, Michael Kühn, Thorsten Lee, Han-Byoel Loibl, Sibylle Mannhart, Meinrad Meattini, Icro Montagna, Giacomo Pinker, Katja Poulakaki, Fiorita Rubio, Isabel T. Sager, Patrizia Steyerova, Petra Tausch, Christoph Tramm, Trine Vrancken Peeters, Marie-Jeanne Wyld, Lynda Yu, Jong Han Weber, Walter Paul Poortmans, Philip Dubsky, Peter |
author_facet | Kaidar-Person, Orit Pfob, André Gentilini, Oreste Davide Borisch, Bettina Bosch, Ana Cardoso, Maria João Curigliano, Giuseppe De Boniface, Jana Denkert, Carsten Hauser, Nik Heil, Jörg Knauer, Michael Kühn, Thorsten Lee, Han-Byoel Loibl, Sibylle Mannhart, Meinrad Meattini, Icro Montagna, Giacomo Pinker, Katja Poulakaki, Fiorita Rubio, Isabel T. Sager, Patrizia Steyerova, Petra Tausch, Christoph Tramm, Trine Vrancken Peeters, Marie-Jeanne Wyld, Lynda Yu, Jong Han Weber, Walter Paul Poortmans, Philip Dubsky, Peter |
author_sort | Kaidar-Person, Orit |
collection | PubMed |
description | Clinical axillary lymph node management in early breast cancer has evolved from being merely an aspect of surgical management and now includes the entire multidisciplinary team. The second edition of the “Lucerne Toolbox”, a multidisciplinary consortium of European cancer societies and patient representatives, addresses the challenges of clinical axillary lymph node management, from diagnosis to local therapy of the axilla. Five working packages were developed, following the patients’ journey and addressing specific clinical scenarios. Panellists voted on 72 statements, reaching consensus (agreement of 75% or more) in 52.8%, majority (51%–74% agreement) in 43.1%, and no decision in 4.2%. Based on the votes, targeted imaging and standardized pathology of lymph nodes should be a prerequisite to planning local and systemic therapy, axillary lymph node dissection can be replaced by sentinel lymph node biopsy ( ± targeted approaches) in a majority of scenarios; and positive patient outcomes should be driven by both low recurrence risks and low rates of lymphoedema. |
format | Online Article Text |
id | pubmed-10388578 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-103885782023-08-01 The Lucerne Toolbox 2 to optimise axillary management for early breast cancer: a multidisciplinary expert consensus Kaidar-Person, Orit Pfob, André Gentilini, Oreste Davide Borisch, Bettina Bosch, Ana Cardoso, Maria João Curigliano, Giuseppe De Boniface, Jana Denkert, Carsten Hauser, Nik Heil, Jörg Knauer, Michael Kühn, Thorsten Lee, Han-Byoel Loibl, Sibylle Mannhart, Meinrad Meattini, Icro Montagna, Giacomo Pinker, Katja Poulakaki, Fiorita Rubio, Isabel T. Sager, Patrizia Steyerova, Petra Tausch, Christoph Tramm, Trine Vrancken Peeters, Marie-Jeanne Wyld, Lynda Yu, Jong Han Weber, Walter Paul Poortmans, Philip Dubsky, Peter eClinicalMedicine Review Clinical axillary lymph node management in early breast cancer has evolved from being merely an aspect of surgical management and now includes the entire multidisciplinary team. The second edition of the “Lucerne Toolbox”, a multidisciplinary consortium of European cancer societies and patient representatives, addresses the challenges of clinical axillary lymph node management, from diagnosis to local therapy of the axilla. Five working packages were developed, following the patients’ journey and addressing specific clinical scenarios. Panellists voted on 72 statements, reaching consensus (agreement of 75% or more) in 52.8%, majority (51%–74% agreement) in 43.1%, and no decision in 4.2%. Based on the votes, targeted imaging and standardized pathology of lymph nodes should be a prerequisite to planning local and systemic therapy, axillary lymph node dissection can be replaced by sentinel lymph node biopsy ( ± targeted approaches) in a majority of scenarios; and positive patient outcomes should be driven by both low recurrence risks and low rates of lymphoedema. Elsevier 2023-07-14 /pmc/articles/PMC10388578/ /pubmed/37528842 http://dx.doi.org/10.1016/j.eclinm.2023.102085 Text en © 2023 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Review Kaidar-Person, Orit Pfob, André Gentilini, Oreste Davide Borisch, Bettina Bosch, Ana Cardoso, Maria João Curigliano, Giuseppe De Boniface, Jana Denkert, Carsten Hauser, Nik Heil, Jörg Knauer, Michael Kühn, Thorsten Lee, Han-Byoel Loibl, Sibylle Mannhart, Meinrad Meattini, Icro Montagna, Giacomo Pinker, Katja Poulakaki, Fiorita Rubio, Isabel T. Sager, Patrizia Steyerova, Petra Tausch, Christoph Tramm, Trine Vrancken Peeters, Marie-Jeanne Wyld, Lynda Yu, Jong Han Weber, Walter Paul Poortmans, Philip Dubsky, Peter The Lucerne Toolbox 2 to optimise axillary management for early breast cancer: a multidisciplinary expert consensus |
title | The Lucerne Toolbox 2 to optimise axillary management for early breast cancer: a multidisciplinary expert consensus |
title_full | The Lucerne Toolbox 2 to optimise axillary management for early breast cancer: a multidisciplinary expert consensus |
title_fullStr | The Lucerne Toolbox 2 to optimise axillary management for early breast cancer: a multidisciplinary expert consensus |
title_full_unstemmed | The Lucerne Toolbox 2 to optimise axillary management for early breast cancer: a multidisciplinary expert consensus |
title_short | The Lucerne Toolbox 2 to optimise axillary management for early breast cancer: a multidisciplinary expert consensus |
title_sort | lucerne toolbox 2 to optimise axillary management for early breast cancer: a multidisciplinary expert consensus |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10388578/ https://www.ncbi.nlm.nih.gov/pubmed/37528842 http://dx.doi.org/10.1016/j.eclinm.2023.102085 |
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