Uridylation of the histone mRNA stem-loop weakens binding interactions with SLBP while maintaining interactions with 3’hExo

Histone mRNA degradation is controlled by the unique 3’ stem-loop of histone mRNA and the stem-loop binding protein (SLBP). As part of this process, the 3’ stem-loop is trimmed by the histone-specific 3’ exonuclease (3’hExo) and uridylated by the terminal uridylyl transferase 7 (TUT7), creating part...

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Detalles Bibliográficos
Autores principales: Shine, Morgan, Harris, Sarah E., Pellegrene, Kendy A., Kensinger, Adam H., Mihailescu, Mihaela Rita, Evanseck, Jeffrey D., Lackey, Patrick E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10388802/
https://www.ncbi.nlm.nih.gov/pubmed/37516934
http://dx.doi.org/10.1080/15476286.2023.2171760

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