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Atypical complication in an adult patient with dengue and autoimmune hemolytic anemia: a case report

Severe dengue infection is associated with life-threatening complications, including severe bleeding. The bleeding tendency is typically associated with the shock phase of infection, for which blood replacement may be needed. However, repetitive blood transfusion can lead to volume overload. Adminis...

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Autores principales: Chamnanchanunt, Supat, Thungthong, Pravinwan, Nakhakes, Chajchawan, Chonsawat, Putza, Suwanban, Tawatchai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sciendo 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10388806/
https://www.ncbi.nlm.nih.gov/pubmed/37551296
http://dx.doi.org/10.1515/abm-2021-0006
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author Chamnanchanunt, Supat
Thungthong, Pravinwan
Nakhakes, Chajchawan
Chonsawat, Putza
Suwanban, Tawatchai
author_facet Chamnanchanunt, Supat
Thungthong, Pravinwan
Nakhakes, Chajchawan
Chonsawat, Putza
Suwanban, Tawatchai
author_sort Chamnanchanunt, Supat
collection PubMed
description Severe dengue infection is associated with life-threatening complications, including severe bleeding. The bleeding tendency is typically associated with the shock phase of infection, for which blood replacement may be needed. However, repetitive blood transfusion can lead to volume overload. Administration of recombinant activated factor VII (rFVIIa) might be used to counteract bleeding without inducing volume overload. We describe the case of a patient with severe dengue infection who presented with intractable bleeding; he was initially treated with massive blood transfusions, which resulted in volume overload. He was then treated with rFVIIa to reverse the bleeding. During the second week of his hospitalization, his hematocrit dropped precipitously, and autoimmune hemolytic anemia was diagnosed. Supportive treatment was provided until recovery. Autoimmune hemolytic anemia is a rare complication in adult patients with dengue. Supportive care was effective for this atypical complication.
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spelling pubmed-103888062023-08-07 Atypical complication in an adult patient with dengue and autoimmune hemolytic anemia: a case report Chamnanchanunt, Supat Thungthong, Pravinwan Nakhakes, Chajchawan Chonsawat, Putza Suwanban, Tawatchai Asian Biomed (Res Rev News) Clinical Vignette Severe dengue infection is associated with life-threatening complications, including severe bleeding. The bleeding tendency is typically associated with the shock phase of infection, for which blood replacement may be needed. However, repetitive blood transfusion can lead to volume overload. Administration of recombinant activated factor VII (rFVIIa) might be used to counteract bleeding without inducing volume overload. We describe the case of a patient with severe dengue infection who presented with intractable bleeding; he was initially treated with massive blood transfusions, which resulted in volume overload. He was then treated with rFVIIa to reverse the bleeding. During the second week of his hospitalization, his hematocrit dropped precipitously, and autoimmune hemolytic anemia was diagnosed. Supportive treatment was provided until recovery. Autoimmune hemolytic anemia is a rare complication in adult patients with dengue. Supportive care was effective for this atypical complication. Sciendo 2021-02-21 /pmc/articles/PMC10388806/ /pubmed/37551296 http://dx.doi.org/10.1515/abm-2021-0006 Text en © 2021 Supat Chamnanchanunt et al., published by Sciendo https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
spellingShingle Clinical Vignette
Chamnanchanunt, Supat
Thungthong, Pravinwan
Nakhakes, Chajchawan
Chonsawat, Putza
Suwanban, Tawatchai
Atypical complication in an adult patient with dengue and autoimmune hemolytic anemia: a case report
title Atypical complication in an adult patient with dengue and autoimmune hemolytic anemia: a case report
title_full Atypical complication in an adult patient with dengue and autoimmune hemolytic anemia: a case report
title_fullStr Atypical complication in an adult patient with dengue and autoimmune hemolytic anemia: a case report
title_full_unstemmed Atypical complication in an adult patient with dengue and autoimmune hemolytic anemia: a case report
title_short Atypical complication in an adult patient with dengue and autoimmune hemolytic anemia: a case report
title_sort atypical complication in an adult patient with dengue and autoimmune hemolytic anemia: a case report
topic Clinical Vignette
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10388806/
https://www.ncbi.nlm.nih.gov/pubmed/37551296
http://dx.doi.org/10.1515/abm-2021-0006
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