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Inhibition of Microsomal Prostaglandin E2 Synthase Reduces Collagen Deposition in Melanoma Tumors and May Improve Immunotherapy Efficacy by Reducing T-cell Exhaustion

The arachidonic acid pathway participates in immunosuppression in various types of cancer. Our previous observation detailed that microsomal prostaglandin E2 synthase 1 (mPGES-1), an enzyme downstream of cyclooxygenase 2 (COX-2), limited antitumor immunity in melanoma; in addition, genetic depletion...

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Detalles Bibliográficos
Autores principales:	Fukuda, Yasunari, Kim, Sun-Hee, Bustos, Matias A., Cho, Sung-Nam, Roszik, Jason, Burks, Jared K., Kim, Hong, Hoon, Dave S.B., Grimm, Elizabeth A., Ekmekcioglu, Suhendan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for Cancer Research 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10389052/ https://www.ncbi.nlm.nih.gov/pubmed/37529399 http://dx.doi.org/10.1158/2767-9764.CRC-23-0210

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