Early lyophilized cryoprecipitate enhances the ADAMTS13/VWF ratio to reduce systemic endotheliopathy and lessen lung injury in a mouse multiple-trauma hemorrhage model

Recent studies in severely injured patients suggest an important role of von Willebrand Factor (VWF) and ADAMTS13 in the endotheliopathy of trauma (EoT). We hypothesized that the early use of cryoprecipitate would be effective as an endothelial protector by supplementing physiologic VWF and ADAMTS13...

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Detalles Bibliográficos
Autores principales: Zeineddin, Ahmad, Wu, Feng, Dong, Jing-Fei, Vesselinov, Roumen, Neal, Matthew D., Corash, Laurence, Pati, Shibani, Kozar, Rosemary A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10389395/
https://www.ncbi.nlm.nih.gov/pubmed/37211640
http://dx.doi.org/10.1097/TA.0000000000004065

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