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Inflammatory score predicts early hematoma expansion and poor outcomes in patients with intracerebral hemorrhage

This study aimed to develop a prediction score named inflammatory score based on proper integration of several inflammatory markers and investigate whether it was associated with hematoma expansion and poor outcomes in patients with intracerebral hemorrhage (ICH). METHODS: This study involved a cons...

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Autores principales: Chu, Heling, Huang, Chuyi, Zhou, Zaiying, Tang, Yuping, Dong, Qiang, Guo, Qihao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10389560/
https://www.ncbi.nlm.nih.gov/pubmed/37093070
http://dx.doi.org/10.1097/JS9.0000000000000191
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author Chu, Heling
Huang, Chuyi
Zhou, Zaiying
Tang, Yuping
Dong, Qiang
Guo, Qihao
author_facet Chu, Heling
Huang, Chuyi
Zhou, Zaiying
Tang, Yuping
Dong, Qiang
Guo, Qihao
author_sort Chu, Heling
collection PubMed
description This study aimed to develop a prediction score named inflammatory score based on proper integration of several inflammatory markers and investigate whether it was associated with hematoma expansion and poor outcomes in patients with intracerebral hemorrhage (ICH). METHODS: This study involved a consecutive series of spontaneous ICH patients of two cohorts admitted within 24 hours after symptom onset. Inflammatory score (0–9) was developed with the combination of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, monocyte-to-lymphocyte ratio, systemic immune-inflammation index, lactate dehydrogenase, and C-reactive protein. The authors investigated the association between inflammatory score and hematoma expansion and poor outcomes by using univariate and multivariate logistic regression analyses. The optimal cutoff point of inflammatory score was determined by receiver operating characteristic analysis in the development cohort and then validated. RESULTS: A total of 301 and 154 ICH patients were enrolled in the development and validation cohorts. Inflammatory score was significantly higher in patients with hematoma expansion and poor outcomes. The multivariate logistic regression analysis revealed inflammatory score was independently associated with hematoma expansion, secondary neurological deterioration within 48 hours, 30-day mortality, and 3-month poor modified Rankin scale (4–6). The diagnostic accuracy of inflammatory score exhibited by area under the curve showed numerically or statistically higher than most of the individual indicators. Moreover, inflammatory score greater than or equal to 5 was selected as the optimal cutoff point, which was further prospectively validated with high diagnostic accuracy. CONCLUSIONS: The inflammatory score is a reliable predictor for early hematoma expansion and short-term and long-term poor outcomes with good diagnostic accuracies in ICH patients.
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spelling pubmed-103895602023-08-01 Inflammatory score predicts early hematoma expansion and poor outcomes in patients with intracerebral hemorrhage Chu, Heling Huang, Chuyi Zhou, Zaiying Tang, Yuping Dong, Qiang Guo, Qihao Int J Surg Original Research This study aimed to develop a prediction score named inflammatory score based on proper integration of several inflammatory markers and investigate whether it was associated with hematoma expansion and poor outcomes in patients with intracerebral hemorrhage (ICH). METHODS: This study involved a consecutive series of spontaneous ICH patients of two cohorts admitted within 24 hours after symptom onset. Inflammatory score (0–9) was developed with the combination of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, monocyte-to-lymphocyte ratio, systemic immune-inflammation index, lactate dehydrogenase, and C-reactive protein. The authors investigated the association between inflammatory score and hematoma expansion and poor outcomes by using univariate and multivariate logistic regression analyses. The optimal cutoff point of inflammatory score was determined by receiver operating characteristic analysis in the development cohort and then validated. RESULTS: A total of 301 and 154 ICH patients were enrolled in the development and validation cohorts. Inflammatory score was significantly higher in patients with hematoma expansion and poor outcomes. The multivariate logistic regression analysis revealed inflammatory score was independently associated with hematoma expansion, secondary neurological deterioration within 48 hours, 30-day mortality, and 3-month poor modified Rankin scale (4–6). The diagnostic accuracy of inflammatory score exhibited by area under the curve showed numerically or statistically higher than most of the individual indicators. Moreover, inflammatory score greater than or equal to 5 was selected as the optimal cutoff point, which was further prospectively validated with high diagnostic accuracy. CONCLUSIONS: The inflammatory score is a reliable predictor for early hematoma expansion and short-term and long-term poor outcomes with good diagnostic accuracies in ICH patients. Lippincott Williams & Wilkins 2023-03-24 /pmc/articles/PMC10389560/ /pubmed/37093070 http://dx.doi.org/10.1097/JS9.0000000000000191 Text en Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Original Research
Chu, Heling
Huang, Chuyi
Zhou, Zaiying
Tang, Yuping
Dong, Qiang
Guo, Qihao
Inflammatory score predicts early hematoma expansion and poor outcomes in patients with intracerebral hemorrhage
title Inflammatory score predicts early hematoma expansion and poor outcomes in patients with intracerebral hemorrhage
title_full Inflammatory score predicts early hematoma expansion and poor outcomes in patients with intracerebral hemorrhage
title_fullStr Inflammatory score predicts early hematoma expansion and poor outcomes in patients with intracerebral hemorrhage
title_full_unstemmed Inflammatory score predicts early hematoma expansion and poor outcomes in patients with intracerebral hemorrhage
title_short Inflammatory score predicts early hematoma expansion and poor outcomes in patients with intracerebral hemorrhage
title_sort inflammatory score predicts early hematoma expansion and poor outcomes in patients with intracerebral hemorrhage
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10389560/
https://www.ncbi.nlm.nih.gov/pubmed/37093070
http://dx.doi.org/10.1097/JS9.0000000000000191
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