Oligomeric β-Amyloid Suppresses Hippocampal γ-Oscillations through Activation of the mTOR/S6K1 Pathway

Neuronal synchronization at gamma frequency (30-100 Hz: γ) is impaired in early-stage Alzheimer's disease (AD) patients and AD models. Oligomeric Aβ(1-42) caused a concentration-dependent reduction of γ-oscillation strength and regularity while increasing its frequency. The mTOR1 inhibitor rapa...

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Detalles Bibliográficos
Autores principales: Wang, Ya-Li, Wang, Jian-Gang, Guo, Shuling, Guo, Fang-Li, Liu, En-Jie, Yang, Xin, Feng, Bingyan, Wang, Jian-Zhi, Vreugdenhil, Martin, Lu, Cheng-Biao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: JKL International LLC 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10389838/
https://www.ncbi.nlm.nih.gov/pubmed/37163441
http://dx.doi.org/10.14336/AD.2023.0123

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10389838/
https://www.ncbi.nlm.nih.gov/pubmed/37163441
http://dx.doi.org/10.14336/AD.2023.0123

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