Inhibition of DNMT1 methyltransferase activity via glucose-regulated O-GlcNAcylation alters the epigenome

The DNA methyltransferase activity of DNMT1 is vital for genomic maintenance of DNA methylation. We report here that DNMT1 function is regulated by O-GlcNAcylation, a protein modification that is sensitive to glucose levels, and that elevated O-GlcNAcylation of DNMT1 from high glucose environment le...

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Detalles Bibliográficos
Autores principales: Shin, Heon, Leung, Amy, Costello, Kevin R, Senapati, Parijat, Kato, Hiroyuki, Moore, Roger E, Lee, Michael, Lin, Dimitri, Tang, Xiaofang, Pirrotte, Patrick, Bouman Chen, Zhen, Schones, Dustin E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Chromosomes and Gene Expression
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10390045/
https://www.ncbi.nlm.nih.gov/pubmed/37470704
http://dx.doi.org/10.7554/eLife.85595

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