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Major chemical constituents from Illicium griffithii Hook. f. & Thoms of North East India and their cytotoxicity and antimicrobial activities
Illicium griffithii Hook. f. & Thoms is an endemic medicinal plant of North East India found in the Eastern Himalayan region of biodiversity mega centre. Herein, chemical investigation of I. griffithii, afforded five compounds and their structures were determined through extensive use of NMR, HR...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Scientific and Technological Research Council of Turkey (TUBITAK)
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10390145/ https://www.ncbi.nlm.nih.gov/pubmed/37529743 http://dx.doi.org/10.55730/1300-0527.3451 |
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author | DUTTA, Deepjyoti NARZARY, Bardwi SAIKIA, Snigdha TAMULI, Kashyap Jyoti BORDOLOI, Manobjyoti LHOUVUM, Neipihoi NATH, Shyamalendu SAHOO, Ranjan Kumar GOGOI, Barnali SAIKIA, Surovi BHATTACHARYYA, Nayan Kamal |
author_facet | DUTTA, Deepjyoti NARZARY, Bardwi SAIKIA, Snigdha TAMULI, Kashyap Jyoti BORDOLOI, Manobjyoti LHOUVUM, Neipihoi NATH, Shyamalendu SAHOO, Ranjan Kumar GOGOI, Barnali SAIKIA, Surovi BHATTACHARYYA, Nayan Kamal |
author_sort | DUTTA, Deepjyoti |
collection | PubMed |
description | Illicium griffithii Hook. f. & Thoms is an endemic medicinal plant of North East India found in the Eastern Himalayan region of biodiversity mega centre. Herein, chemical investigation of I. griffithii, afforded five compounds and their structures were determined through extensive use of NMR, HRMS, and FT-IR spectroscopy. The complete proton-proton, proton-carbon coupling network of compound 1 was determined using (1)H-(1)H COSY, HSQC and NOESY NMR experiments. All the compounds were evaluated for their cytotoxic activity by MTT assay and antimicrobial activity by Agar well diffusion method. Compound 1 exhibited significant cytotoxicity activity against Lung cancer (A549) and pancreatic cancer (MIAPaCa2) cell lines with IC(50) values of 15.01 ± 2.69 μg/mL and 47.77 ± 2.38 μg/mL, respectively. Further, the compound 1 exhibited good antimicrobial activities against Escherichia coli and Candida albicans with MIC 7.50 ± 0.28 μg/mL and 7.50 ± 0.86 μg/mL, respectively. The other isolated compounds along with the extracts of I. griffithii also displayed moderate anticancer and antimicrobial activities against respective strains. To the best of our knowledge, this is the first study of isolation of compounds from bark, wood, and leaf along with cytotoxicity and antimicrobial activities of I. griffithii from the North Eastern region of India and could be a potential herbal medicine in near future. |
format | Online Article Text |
id | pubmed-10390145 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Scientific and Technological Research Council of Turkey (TUBITAK) |
record_format | MEDLINE/PubMed |
spelling | pubmed-103901452023-08-01 Major chemical constituents from Illicium griffithii Hook. f. & Thoms of North East India and their cytotoxicity and antimicrobial activities DUTTA, Deepjyoti NARZARY, Bardwi SAIKIA, Snigdha TAMULI, Kashyap Jyoti BORDOLOI, Manobjyoti LHOUVUM, Neipihoi NATH, Shyamalendu SAHOO, Ranjan Kumar GOGOI, Barnali SAIKIA, Surovi BHATTACHARYYA, Nayan Kamal Turk J Chem Research Article Illicium griffithii Hook. f. & Thoms is an endemic medicinal plant of North East India found in the Eastern Himalayan region of biodiversity mega centre. Herein, chemical investigation of I. griffithii, afforded five compounds and their structures were determined through extensive use of NMR, HRMS, and FT-IR spectroscopy. The complete proton-proton, proton-carbon coupling network of compound 1 was determined using (1)H-(1)H COSY, HSQC and NOESY NMR experiments. All the compounds were evaluated for their cytotoxic activity by MTT assay and antimicrobial activity by Agar well diffusion method. Compound 1 exhibited significant cytotoxicity activity against Lung cancer (A549) and pancreatic cancer (MIAPaCa2) cell lines with IC(50) values of 15.01 ± 2.69 μg/mL and 47.77 ± 2.38 μg/mL, respectively. Further, the compound 1 exhibited good antimicrobial activities against Escherichia coli and Candida albicans with MIC 7.50 ± 0.28 μg/mL and 7.50 ± 0.86 μg/mL, respectively. The other isolated compounds along with the extracts of I. griffithii also displayed moderate anticancer and antimicrobial activities against respective strains. To the best of our knowledge, this is the first study of isolation of compounds from bark, wood, and leaf along with cytotoxicity and antimicrobial activities of I. griffithii from the North Eastern region of India and could be a potential herbal medicine in near future. Scientific and Technological Research Council of Turkey (TUBITAK) 2022-04-08 /pmc/articles/PMC10390145/ /pubmed/37529743 http://dx.doi.org/10.55730/1300-0527.3451 Text en © TÜBİTAK https://creativecommons.org/licenses/by/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License. |
spellingShingle | Research Article DUTTA, Deepjyoti NARZARY, Bardwi SAIKIA, Snigdha TAMULI, Kashyap Jyoti BORDOLOI, Manobjyoti LHOUVUM, Neipihoi NATH, Shyamalendu SAHOO, Ranjan Kumar GOGOI, Barnali SAIKIA, Surovi BHATTACHARYYA, Nayan Kamal Major chemical constituents from Illicium griffithii Hook. f. & Thoms of North East India and their cytotoxicity and antimicrobial activities |
title | Major chemical constituents from Illicium griffithii Hook. f. & Thoms of North East India and their cytotoxicity and antimicrobial activities |
title_full | Major chemical constituents from Illicium griffithii Hook. f. & Thoms of North East India and their cytotoxicity and antimicrobial activities |
title_fullStr | Major chemical constituents from Illicium griffithii Hook. f. & Thoms of North East India and their cytotoxicity and antimicrobial activities |
title_full_unstemmed | Major chemical constituents from Illicium griffithii Hook. f. & Thoms of North East India and their cytotoxicity and antimicrobial activities |
title_short | Major chemical constituents from Illicium griffithii Hook. f. & Thoms of North East India and their cytotoxicity and antimicrobial activities |
title_sort | major chemical constituents from illicium griffithii hook. f. & thoms of north east india and their cytotoxicity and antimicrobial activities |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10390145/ https://www.ncbi.nlm.nih.gov/pubmed/37529743 http://dx.doi.org/10.55730/1300-0527.3451 |
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