Cargando…
Can surfactants affect mortality and morbidity in term infants with respiratory failure?
BACKGROUND/AIM: We aimed to discuss term infants who are given surfactant due to respiratory disorder according to the underlying etiology, the dose of surfactant administration, and the need for repeated surfactant administration. MATERIALS AND METHODS: In this retrospective study infants hospitali...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Scientific and Technological Research Council of Turkey (TUBITAK)
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10390193/ https://www.ncbi.nlm.nih.gov/pubmed/36945972 http://dx.doi.org/10.55730/1300-0144.5523 |
_version_ | 1785082427274690560 |
---|---|
author | ALKAN ÖZDEMİR, Senem YILMAN, Özlem ÇALKAVUR, Şebnem GÖKMEN YILDIRIM, Tülin |
author_facet | ALKAN ÖZDEMİR, Senem YILMAN, Özlem ÇALKAVUR, Şebnem GÖKMEN YILDIRIM, Tülin |
author_sort | ALKAN ÖZDEMİR, Senem |
collection | PubMed |
description | BACKGROUND/AIM: We aimed to discuss term infants who are given surfactant due to respiratory disorder according to the underlying etiology, the dose of surfactant administration, and the need for repeated surfactant administration. MATERIALS AND METHODS: In this retrospective study infants hospitalized in the 4th level neonatal intensive care unit during January 2019 and December 2021 and administered surfactant due to respiratory distress were included. Term infants given surfactant due to respiratory failure were included in the study through the data recording system. The number of surfactant doses, indications for administration, mortality, duration of hospitalization, intubation time, and inotrope use were recorded in the infants included in the study. RESULTS: During the two-year period, 1250 infants were hospitalized in our neonatal intensive care unit. Of those, 56 infants received surfactant replacement therapy for severe respiratory failure. There were 30 infants with pneumonia, 4 infants with meconium aspiration syndrome (MAS), and 22 infants with transient tachypnea of the newborn (TTN). It was seen that single-dose administration was higher in patients with TTN (p = 0.01), while multiple-dose surfactant administration was more common in patients with MAS, resulting in a statistical difference (p = 0.02). Mortality was lower, especially in cases given early surfactant administration and this situation was statistically significant (p < 0.001). Duration of intubation was 5.05 ± 4.7 days in early surfactant administration group and 8.0 ± 6.1 days in late surfactant administration group. This difference was statistically significant (p = 0.04). While early surfactant application was statistically higher in the TTN group (p = 0.007), late surfactant application was statistically higher in the pneumonia group (p = 0.001). CONCLUSION: Despite the difference on administration time and repeat dose interval due to etiology, surfactant treatment is improving the respiratory distress of term infants. |
format | Online Article Text |
id | pubmed-10390193 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Scientific and Technological Research Council of Turkey (TUBITAK) |
record_format | MEDLINE/PubMed |
spelling | pubmed-103901932023-08-01 Can surfactants affect mortality and morbidity in term infants with respiratory failure? ALKAN ÖZDEMİR, Senem YILMAN, Özlem ÇALKAVUR, Şebnem GÖKMEN YILDIRIM, Tülin Turk J Med Sci Research Article BACKGROUND/AIM: We aimed to discuss term infants who are given surfactant due to respiratory disorder according to the underlying etiology, the dose of surfactant administration, and the need for repeated surfactant administration. MATERIALS AND METHODS: In this retrospective study infants hospitalized in the 4th level neonatal intensive care unit during January 2019 and December 2021 and administered surfactant due to respiratory distress were included. Term infants given surfactant due to respiratory failure were included in the study through the data recording system. The number of surfactant doses, indications for administration, mortality, duration of hospitalization, intubation time, and inotrope use were recorded in the infants included in the study. RESULTS: During the two-year period, 1250 infants were hospitalized in our neonatal intensive care unit. Of those, 56 infants received surfactant replacement therapy for severe respiratory failure. There were 30 infants with pneumonia, 4 infants with meconium aspiration syndrome (MAS), and 22 infants with transient tachypnea of the newborn (TTN). It was seen that single-dose administration was higher in patients with TTN (p = 0.01), while multiple-dose surfactant administration was more common in patients with MAS, resulting in a statistical difference (p = 0.02). Mortality was lower, especially in cases given early surfactant administration and this situation was statistically significant (p < 0.001). Duration of intubation was 5.05 ± 4.7 days in early surfactant administration group and 8.0 ± 6.1 days in late surfactant administration group. This difference was statistically significant (p = 0.04). While early surfactant application was statistically higher in the TTN group (p = 0.007), late surfactant application was statistically higher in the pneumonia group (p = 0.001). CONCLUSION: Despite the difference on administration time and repeat dose interval due to etiology, surfactant treatment is improving the respiratory distress of term infants. Scientific and Technological Research Council of Turkey (TUBITAK) 2022-10-22 /pmc/articles/PMC10390193/ /pubmed/36945972 http://dx.doi.org/10.55730/1300-0144.5523 Text en © TÜBİTAK https://creativecommons.org/licenses/by/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License. |
spellingShingle | Research Article ALKAN ÖZDEMİR, Senem YILMAN, Özlem ÇALKAVUR, Şebnem GÖKMEN YILDIRIM, Tülin Can surfactants affect mortality and morbidity in term infants with respiratory failure? |
title | Can surfactants affect mortality and morbidity in term infants with respiratory failure? |
title_full | Can surfactants affect mortality and morbidity in term infants with respiratory failure? |
title_fullStr | Can surfactants affect mortality and morbidity in term infants with respiratory failure? |
title_full_unstemmed | Can surfactants affect mortality and morbidity in term infants with respiratory failure? |
title_short | Can surfactants affect mortality and morbidity in term infants with respiratory failure? |
title_sort | can surfactants affect mortality and morbidity in term infants with respiratory failure? |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10390193/ https://www.ncbi.nlm.nih.gov/pubmed/36945972 http://dx.doi.org/10.55730/1300-0144.5523 |
work_keys_str_mv | AT alkanozdemirsenem cansurfactantsaffectmortalityandmorbidityinterminfantswithrespiratoryfailure AT yilmanozlem cansurfactantsaffectmortalityandmorbidityinterminfantswithrespiratoryfailure AT calkavursebnem cansurfactantsaffectmortalityandmorbidityinterminfantswithrespiratoryfailure AT gokmenyildirimtulin cansurfactantsaffectmortalityandmorbidityinterminfantswithrespiratoryfailure |