Cargando…
Anti-migration and anti-invasion effects of LY-290181 on breast cancer cell lines through the inhibition of Twist1
Breast cancer has become the most common cancer among women worldwide. Among breast cancers, metastatic breast cancer is associated with the highest mortality rate. Twist1, one of the epithelial-mesenchymal transition-regulating transcription factors, is known to promote the intravasation of breast...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Society for Biochemistry and Molecular Biology
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10390291/ https://www.ncbi.nlm.nih.gov/pubmed/37357535 http://dx.doi.org/10.5483/BMBRep.2023-0011 |
_version_ | 1785082447778545664 |
---|---|
author | Park, Jiyoung Lee, Sewoong Yoon, Haelim Kang, Eunjeong Cho, Sayeon |
author_facet | Park, Jiyoung Lee, Sewoong Yoon, Haelim Kang, Eunjeong Cho, Sayeon |
author_sort | Park, Jiyoung |
collection | PubMed |
description | Breast cancer has become the most common cancer among women worldwide. Among breast cancers, metastatic breast cancer is associated with the highest mortality rate. Twist1, one of the epithelial-mesenchymal transition-regulating transcription factors, is known to promote the intravasation of breast cancer cells into metastatic sites. Therefore, targeting Twist1 to develop anti-cancer drugs might be a valuable strategy. In this study, LY-290181 dose-dependently inhibited migration, invasion, and multicellular tumor spheroid invasion in breast cancer cell lines. These anti-cancer effects of LY-290181 were mediated through the down-regulation of Twist1 protein levels. LY-290181 inhibited extracellular signal-regulated kinase and c-Jun N-terminal kinase signaling pathways. Therefore, our findings suggest that LY-290181 may serve as a basis for future research and development of an anti-cancer agent targeting metastatic cancers. |
format | Online Article Text |
id | pubmed-10390291 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Korean Society for Biochemistry and Molecular Biology |
record_format | MEDLINE/PubMed |
spelling | pubmed-103902912023-08-01 Anti-migration and anti-invasion effects of LY-290181 on breast cancer cell lines through the inhibition of Twist1 Park, Jiyoung Lee, Sewoong Yoon, Haelim Kang, Eunjeong Cho, Sayeon BMB Rep Article Breast cancer has become the most common cancer among women worldwide. Among breast cancers, metastatic breast cancer is associated with the highest mortality rate. Twist1, one of the epithelial-mesenchymal transition-regulating transcription factors, is known to promote the intravasation of breast cancer cells into metastatic sites. Therefore, targeting Twist1 to develop anti-cancer drugs might be a valuable strategy. In this study, LY-290181 dose-dependently inhibited migration, invasion, and multicellular tumor spheroid invasion in breast cancer cell lines. These anti-cancer effects of LY-290181 were mediated through the down-regulation of Twist1 protein levels. LY-290181 inhibited extracellular signal-regulated kinase and c-Jun N-terminal kinase signaling pathways. Therefore, our findings suggest that LY-290181 may serve as a basis for future research and development of an anti-cancer agent targeting metastatic cancers. Korean Society for Biochemistry and Molecular Biology 2023-07-31 2023-07-31 /pmc/articles/PMC10390291/ /pubmed/37357535 http://dx.doi.org/10.5483/BMBRep.2023-0011 Text en Copyright © 2023 by the The Korean Society for Biochemistry and Molecular Biology https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Article Park, Jiyoung Lee, Sewoong Yoon, Haelim Kang, Eunjeong Cho, Sayeon Anti-migration and anti-invasion effects of LY-290181 on breast cancer cell lines through the inhibition of Twist1 |
title | Anti-migration and anti-invasion effects of LY-290181 on breast cancer cell lines through the inhibition of Twist1 |
title_full | Anti-migration and anti-invasion effects of LY-290181 on breast cancer cell lines through the inhibition of Twist1 |
title_fullStr | Anti-migration and anti-invasion effects of LY-290181 on breast cancer cell lines through the inhibition of Twist1 |
title_full_unstemmed | Anti-migration and anti-invasion effects of LY-290181 on breast cancer cell lines through the inhibition of Twist1 |
title_short | Anti-migration and anti-invasion effects of LY-290181 on breast cancer cell lines through the inhibition of Twist1 |
title_sort | anti-migration and anti-invasion effects of ly-290181 on breast cancer cell lines through the inhibition of twist1 |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10390291/ https://www.ncbi.nlm.nih.gov/pubmed/37357535 http://dx.doi.org/10.5483/BMBRep.2023-0011 |
work_keys_str_mv | AT parkjiyoung antimigrationandantiinvasioneffectsofly290181onbreastcancercelllinesthroughtheinhibitionoftwist1 AT leesewoong antimigrationandantiinvasioneffectsofly290181onbreastcancercelllinesthroughtheinhibitionoftwist1 AT yoonhaelim antimigrationandantiinvasioneffectsofly290181onbreastcancercelllinesthroughtheinhibitionoftwist1 AT kangeunjeong antimigrationandantiinvasioneffectsofly290181onbreastcancercelllinesthroughtheinhibitionoftwist1 AT chosayeon antimigrationandantiinvasioneffectsofly290181onbreastcancercelllinesthroughtheinhibitionoftwist1 |