Cargando…
Prognosis prediction and comparison between pancreatic signet ring cell carcinoma and pancreatic duct adenocarcinoma: a retrospective observational study
BACKGROUND: Pancreatic signet ring cell carcinoma (PSRCC) is a rare and aggressive cancer that has been reported primarily as case reports. Due to limited large-scale epidemiological and prognostic analyses, the outcomes of PSRCC patients varies greatly in the absence of recognized first-line treatm...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10390323/ https://www.ncbi.nlm.nih.gov/pubmed/37534212 http://dx.doi.org/10.3389/fendo.2023.1205594 |
_version_ | 1785082455213998080 |
---|---|
author | Zhou, Hui Li, Xiao-xue Huang, Yun-peng Wang, Yong-xiang Zou, Heng Xiong, Li Liu, Zhong-tao Wen, Yu Zhang, Zi-jian |
author_facet | Zhou, Hui Li, Xiao-xue Huang, Yun-peng Wang, Yong-xiang Zou, Heng Xiong, Li Liu, Zhong-tao Wen, Yu Zhang, Zi-jian |
author_sort | Zhou, Hui |
collection | PubMed |
description | BACKGROUND: Pancreatic signet ring cell carcinoma (PSRCC) is a rare and aggressive cancer that has been reported primarily as case reports. Due to limited large-scale epidemiological and prognostic analyses, the outcomes of PSRCC patients varies greatly in the absence of recognized first-line treatment strategies. This study aimed to compare the clinical features, treatment, and prognosis of PSRCC and pancreatic ductal cell carcinoma (PDAC), the most common subtype of pancreatic cancer, and to establish predictive models for these subtypes. METHODS: The data on PSRCC and PDAC patients from 1998 to 2018 was obtained from the Surveillance, Epidemiology, and End Results (SEER) database. Thereafter, the clinical, demographic, and treatment characteristics of the two groups and the differences and influencing factors of the two groups were evaluated by propensity score matching (PSM), Kaplan–Meier survival curves, Cox risk regression analyses, and least absolute shrinkage and selection operator (LASSO) analysis. Next, prognosis models were constructed and validated by KM and ROC analysis. Finally, a nomogram was constructed, based on the results of these analyses, to predict survival outcomes of PSRCC and PDAC patients. RESULTS: A total of 84,789 patients (432 PSRCC and 84357 PDAC patients) were included in this study. The results of the study revealed that, compared to the PDAC patients, PSRCC patients were more likely to be male, aged between 58–72 years, have larger tumor masses, and less likely to undergo chemotherapy. Before PSM, the overall survival and cancer-specific survival of the PSRCC group were significantly lower than those PDAC group, but there was no difference in the prognosis of the two groups after PSM. Additionally, lymph node ratio (LNR), log odds of positive lymph node (LODDS), tumor size, age, T-stage, marital status, and summary stage were found to be independent prognostic factors for PSRCC. Lastly, the prediction model and nomogram based on these prognostic factors could accurately predict the survival rate of the patients in SEER datasets and external validation datasets. CONCLUSION: The prognosis of PSRCC and PDAC patients is similar under the same conditions; however, PSRCC patients may have more difficulty in receiving better treatment, thus resulting in their poor prognosis. |
format | Online Article Text |
id | pubmed-10390323 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-103903232023-08-02 Prognosis prediction and comparison between pancreatic signet ring cell carcinoma and pancreatic duct adenocarcinoma: a retrospective observational study Zhou, Hui Li, Xiao-xue Huang, Yun-peng Wang, Yong-xiang Zou, Heng Xiong, Li Liu, Zhong-tao Wen, Yu Zhang, Zi-jian Front Endocrinol (Lausanne) Endocrinology BACKGROUND: Pancreatic signet ring cell carcinoma (PSRCC) is a rare and aggressive cancer that has been reported primarily as case reports. Due to limited large-scale epidemiological and prognostic analyses, the outcomes of PSRCC patients varies greatly in the absence of recognized first-line treatment strategies. This study aimed to compare the clinical features, treatment, and prognosis of PSRCC and pancreatic ductal cell carcinoma (PDAC), the most common subtype of pancreatic cancer, and to establish predictive models for these subtypes. METHODS: The data on PSRCC and PDAC patients from 1998 to 2018 was obtained from the Surveillance, Epidemiology, and End Results (SEER) database. Thereafter, the clinical, demographic, and treatment characteristics of the two groups and the differences and influencing factors of the two groups were evaluated by propensity score matching (PSM), Kaplan–Meier survival curves, Cox risk regression analyses, and least absolute shrinkage and selection operator (LASSO) analysis. Next, prognosis models were constructed and validated by KM and ROC analysis. Finally, a nomogram was constructed, based on the results of these analyses, to predict survival outcomes of PSRCC and PDAC patients. RESULTS: A total of 84,789 patients (432 PSRCC and 84357 PDAC patients) were included in this study. The results of the study revealed that, compared to the PDAC patients, PSRCC patients were more likely to be male, aged between 58–72 years, have larger tumor masses, and less likely to undergo chemotherapy. Before PSM, the overall survival and cancer-specific survival of the PSRCC group were significantly lower than those PDAC group, but there was no difference in the prognosis of the two groups after PSM. Additionally, lymph node ratio (LNR), log odds of positive lymph node (LODDS), tumor size, age, T-stage, marital status, and summary stage were found to be independent prognostic factors for PSRCC. Lastly, the prediction model and nomogram based on these prognostic factors could accurately predict the survival rate of the patients in SEER datasets and external validation datasets. CONCLUSION: The prognosis of PSRCC and PDAC patients is similar under the same conditions; however, PSRCC patients may have more difficulty in receiving better treatment, thus resulting in their poor prognosis. Frontiers Media S.A. 2023-07-17 /pmc/articles/PMC10390323/ /pubmed/37534212 http://dx.doi.org/10.3389/fendo.2023.1205594 Text en Copyright © 2023 Zhou, Li, Huang, Wang, Zou, Xiong, Liu, Wen and Zhang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Endocrinology Zhou, Hui Li, Xiao-xue Huang, Yun-peng Wang, Yong-xiang Zou, Heng Xiong, Li Liu, Zhong-tao Wen, Yu Zhang, Zi-jian Prognosis prediction and comparison between pancreatic signet ring cell carcinoma and pancreatic duct adenocarcinoma: a retrospective observational study |
title | Prognosis prediction and comparison between pancreatic signet ring cell carcinoma and pancreatic duct adenocarcinoma: a retrospective observational study |
title_full | Prognosis prediction and comparison between pancreatic signet ring cell carcinoma and pancreatic duct adenocarcinoma: a retrospective observational study |
title_fullStr | Prognosis prediction and comparison between pancreatic signet ring cell carcinoma and pancreatic duct adenocarcinoma: a retrospective observational study |
title_full_unstemmed | Prognosis prediction and comparison between pancreatic signet ring cell carcinoma and pancreatic duct adenocarcinoma: a retrospective observational study |
title_short | Prognosis prediction and comparison between pancreatic signet ring cell carcinoma and pancreatic duct adenocarcinoma: a retrospective observational study |
title_sort | prognosis prediction and comparison between pancreatic signet ring cell carcinoma and pancreatic duct adenocarcinoma: a retrospective observational study |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10390323/ https://www.ncbi.nlm.nih.gov/pubmed/37534212 http://dx.doi.org/10.3389/fendo.2023.1205594 |
work_keys_str_mv | AT zhouhui prognosispredictionandcomparisonbetweenpancreaticsignetringcellcarcinomaandpancreaticductadenocarcinomaaretrospectiveobservationalstudy AT lixiaoxue prognosispredictionandcomparisonbetweenpancreaticsignetringcellcarcinomaandpancreaticductadenocarcinomaaretrospectiveobservationalstudy AT huangyunpeng prognosispredictionandcomparisonbetweenpancreaticsignetringcellcarcinomaandpancreaticductadenocarcinomaaretrospectiveobservationalstudy AT wangyongxiang prognosispredictionandcomparisonbetweenpancreaticsignetringcellcarcinomaandpancreaticductadenocarcinomaaretrospectiveobservationalstudy AT zouheng prognosispredictionandcomparisonbetweenpancreaticsignetringcellcarcinomaandpancreaticductadenocarcinomaaretrospectiveobservationalstudy AT xiongli prognosispredictionandcomparisonbetweenpancreaticsignetringcellcarcinomaandpancreaticductadenocarcinomaaretrospectiveobservationalstudy AT liuzhongtao prognosispredictionandcomparisonbetweenpancreaticsignetringcellcarcinomaandpancreaticductadenocarcinomaaretrospectiveobservationalstudy AT wenyu prognosispredictionandcomparisonbetweenpancreaticsignetringcellcarcinomaandpancreaticductadenocarcinomaaretrospectiveobservationalstudy AT zhangzijian prognosispredictionandcomparisonbetweenpancreaticsignetringcellcarcinomaandpancreaticductadenocarcinomaaretrospectiveobservationalstudy |