Allergen-induced NLRP3/caspase1/IL-18 signaling initiate eosinophilic esophagitis and respective inhibitors protect disease pathogenesis

The current report describes a stepwise mechanistic pathway of NLRP3/caspase1/IL-18-regulated immune responses operational in eosinophilic esophagitis (EoE). We show that esophageal epithelial cells and macrophage-derived NLRP3 regulated IL-18 initiate the disease and induced IL-5 facilitates eosino...

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Detalles Bibliográficos
Autores principales: Yadavalli, Chandra Sekhar, Upparahalli Venkateshaiah, Sathisha, Kumar, Sandeep, Kandikattu, Hemanth Kumar, Oruganti, Lokanatha, Kathera, Chandra Sekhar, Mishra, Anil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10390481/
https://www.ncbi.nlm.nih.gov/pubmed/37524769
http://dx.doi.org/10.1038/s42003-023-05130-4

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