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Design, synthesis, in vitro, and in silico evaluations of benzo[d]imidazole-amide-1,2,3-triazole-N-arylacetamide hybrids as new antidiabetic agents targeting α-glucosidase

α-Glucosidase as a carbohydrate-hydrolase enzyme is a crucial therapeutic target for type 2 diabetes. In this work, benzo[d]imidazole-amide containing 1,2,3-triazole-N-arylacetamide derivatives 8a–n were synthesized and evaluated for their inhibitory activity against α-glucosidase. In vitro α-glucos...

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Detalles Bibliográficos
Autores principales:	Yousefnejad, Faeze, Mohammadi-Moghadam-Goozali, Mahyar, Sayahi, Mohammad Hosein, Halimi, Mohammad, Moazzam, Ali, Mohammadi-Khanaposhtani, Maryam, Mojtabavi, Somayeh, Asadi, Mehdi, Faramarzi, Mohammad Ali, Larijani, Bagher, Amanlou, Massoud, Mahdavi, Mohammad
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10390517/ https://www.ncbi.nlm.nih.gov/pubmed/37524733 http://dx.doi.org/10.1038/s41598-023-39424-8

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