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Paving the way to better understand the effects of prolonged spaceflight on operational performance and its neural bases

Space exploration objectives will soon move from low Earth orbit to distant destinations like Moon and Mars. The present work provides an up-to-date roadmap that identifies critical research gaps related to human behavior and performance in altered gravity and space. The roadmap summarizes (1) key n...

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Autores principales: Stahn, A. C., Bucher, D., zu Eulenburg, P., Denise, P., Smith, N., Pagnini, F., White, O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10390562/
https://www.ncbi.nlm.nih.gov/pubmed/37524737
http://dx.doi.org/10.1038/s41526-023-00295-y
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author Stahn, A. C.
Bucher, D.
zu Eulenburg, P.
Denise, P.
Smith, N.
Pagnini, F.
White, O.
author_facet Stahn, A. C.
Bucher, D.
zu Eulenburg, P.
Denise, P.
Smith, N.
Pagnini, F.
White, O.
author_sort Stahn, A. C.
collection PubMed
description Space exploration objectives will soon move from low Earth orbit to distant destinations like Moon and Mars. The present work provides an up-to-date roadmap that identifies critical research gaps related to human behavior and performance in altered gravity and space. The roadmap summarizes (1) key neurobehavioral challenges associated with spaceflight, (2) the need to consider sex as a biological variable, (3) the use of integrative omics technologies to elucidate mechanisms underlying changes in the brain and behavior, and (4) the importance of understanding the neural representation of gravity throughout the brain and its multisensory processing. We then highlight the need for a variety of target-specific countermeasures, and a personalized administration schedule as two critical strategies for mitigating potentially adverse effects of spaceflight on the central nervous system and performance. We conclude with a summary of key priorities for the roadmaps of current and future space programs and stress the importance of new collaborative strategies across agencies and researchers for fostering an integrative cross- and transdisciplinary approach from cells, molecules to neural circuits and cognitive performance. Finally, we highlight that space research in neurocognitive science goes beyond monitoring and mitigating risks in astronauts but could also have significant benefits for the population on Earth.
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spelling pubmed-103905622023-08-02 Paving the way to better understand the effects of prolonged spaceflight on operational performance and its neural bases Stahn, A. C. Bucher, D. zu Eulenburg, P. Denise, P. Smith, N. Pagnini, F. White, O. NPJ Microgravity Review Article Space exploration objectives will soon move from low Earth orbit to distant destinations like Moon and Mars. The present work provides an up-to-date roadmap that identifies critical research gaps related to human behavior and performance in altered gravity and space. The roadmap summarizes (1) key neurobehavioral challenges associated with spaceflight, (2) the need to consider sex as a biological variable, (3) the use of integrative omics technologies to elucidate mechanisms underlying changes in the brain and behavior, and (4) the importance of understanding the neural representation of gravity throughout the brain and its multisensory processing. We then highlight the need for a variety of target-specific countermeasures, and a personalized administration schedule as two critical strategies for mitigating potentially adverse effects of spaceflight on the central nervous system and performance. We conclude with a summary of key priorities for the roadmaps of current and future space programs and stress the importance of new collaborative strategies across agencies and researchers for fostering an integrative cross- and transdisciplinary approach from cells, molecules to neural circuits and cognitive performance. Finally, we highlight that space research in neurocognitive science goes beyond monitoring and mitigating risks in astronauts but could also have significant benefits for the population on Earth. Nature Publishing Group UK 2023-07-31 /pmc/articles/PMC10390562/ /pubmed/37524737 http://dx.doi.org/10.1038/s41526-023-00295-y Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Stahn, A. C.
Bucher, D.
zu Eulenburg, P.
Denise, P.
Smith, N.
Pagnini, F.
White, O.
Paving the way to better understand the effects of prolonged spaceflight on operational performance and its neural bases
title Paving the way to better understand the effects of prolonged spaceflight on operational performance and its neural bases
title_full Paving the way to better understand the effects of prolonged spaceflight on operational performance and its neural bases
title_fullStr Paving the way to better understand the effects of prolonged spaceflight on operational performance and its neural bases
title_full_unstemmed Paving the way to better understand the effects of prolonged spaceflight on operational performance and its neural bases
title_short Paving the way to better understand the effects of prolonged spaceflight on operational performance and its neural bases
title_sort paving the way to better understand the effects of prolonged spaceflight on operational performance and its neural bases
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10390562/
https://www.ncbi.nlm.nih.gov/pubmed/37524737
http://dx.doi.org/10.1038/s41526-023-00295-y
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