Multiparametric senescent cell phenotyping reveals targets of senolytic therapy in the aged murine skeleton

Senescence drives organismal aging, yet the deep characterization of senescent cells in vivo remains incomplete. Here, we apply mass cytometry by time-of-flight using carefully validated antibodies to analyze senescent cells at single-cell resolution. We use multiple criteria to identify senescent m...

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Detalles Bibliográficos
Autores principales: Doolittle, Madison L., Saul, Dominik, Kaur, Japneet, Rowsey, Jennifer L., Vos, Stephanie J., Pavelko, Kevin D., Farr, Joshua N., Monroe, David G., Khosla, Sundeep
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10390564/
https://www.ncbi.nlm.nih.gov/pubmed/37524694
http://dx.doi.org/10.1038/s41467-023-40393-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10390564/
https://www.ncbi.nlm.nih.gov/pubmed/37524694
http://dx.doi.org/10.1038/s41467-023-40393-9

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