Cargando…

Utility of genetic risk scores in type 1 diabetes

Iterative advances in understanding of the genetics of type 1 diabetes have identified >70 genetic regions associated with risk of the disease, including strong associations across the HLA class II region that account for >50% of heritability. The increased availability of genetic data combine...

Descripción completa

Detalles Bibliográficos
Autores principales:	Luckett, Amber M., Weedon, Michael N., Hawkes, Gareth, Leslie, R. David, Oram, Richard A., Grant, Struan F. A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2023
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10390619/ https://www.ncbi.nlm.nih.gov/pubmed/37439792 http://dx.doi.org/10.1007/s00125-023-05955-y

Ejemplares similares

A Type 1 Diabetes Genetic Risk Score Predicts Progression of Islet Autoimmunity and Development of Type 1 Diabetes in Individuals at Risk
por: Redondo, Maria J., et al.
Publicado: (2018)

Methods for quick, accurate and cost-effective determination of the type 1 diabetes genetic risk score (T1D-GRS)
por: Locke, Jonathan M., et al.
Publicado: (2020)

Type 1 diabetes genetic risk score is discriminative of diabetes in non-Europeans: evidence from a study in India
por: Harrison, James W., et al.
Publicado: (2020)

Development and Standardization of an Improved Type 1 Diabetes Genetic Risk Score for Use in Newborn Screening and Incident Diagnosis
por: Sharp, Seth A., et al.
Publicado: (2019)

The Dynamic Origins of Type 1 Diabetes
por: Leslie, R. David, et al.
Publicado: (2018)

Genetics of Obesity and Type 2 Diabetes in African Americans
por: McCormack, Shana, et al.
Publicado: (2013)

The TCF7L2 Locus: A Genetic Window Into the Pathogenesis of Type 1 and Type 2 Diabetes
por: Grant, Struan F.A.
Publicado: (2019)

Estimating disease prevalence in large datasets using genetic risk scores
por: Evans, Benjamin D., et al.
Publicado: (2021)

Genetic scores to stratify risk of developing multiple islet autoantibodies and type 1 diabetes: A prospective study in children
por: Bonifacio, Ezio, et al.
Publicado: (2018)

Frequency and phenotype of type 1 diabetes in the first six decades of life: a cross-sectional, genetically stratified survival analysis from UK Biobank
por: Thomas, Nicholas J, et al.
Publicado: (2018)

IgA Nephropathy Genetic Risk Score to Estimate the Prevalence of IgA Nephropathy in UK Biobank
por: Sukcharoen, Kittiya, et al.
Publicado: (2020)

Application of a Genetic Risk Score to Racially Diverse Type 1 Diabetes Populations Demonstrates the Need for Diversity in Risk-Modeling
por: Perry, Daniel J., et al.
Publicado: (2018)

Recurrent 17q12 microduplications contribute to renal disease but not diabetes
por: Cannon, Stuart, et al.
Publicado: (2023)

Teasing Diabetes Apart, One Locus at a Time
por: Leslie, R. David, et al.
Publicado: (2018)

Genetic Susceptibility to Type 2 Diabetes and Obesity: Follow-Up of Findings from Genome-Wide Association Studies
por: Basile, Kevin J., et al.
Publicado: (2014)

The relationship between islet autoantibody status and the genetic risk of type 1 diabetes in adult-onset type 1 diabetes
por: Thomas, Nicholas J., et al.
Publicado: (2022)

Applying a genetic risk score for prostate cancer to men with lower urinary tract symptoms in primary care to predict prostate cancer diagnosis: a cohort study in the UK Biobank
por: Green, Harry D., et al.
Publicado: (2022)

Type 2 Diabetes Genetic Risk Scores Are Associated With Increased Type 2 Diabetes Risk Among African Americans by Cardiometabolic Status
por: Layton, Jill, et al.
Publicado: (2018)

Next steps in the identification of gene targets for type 1 diabetes
por: Grant, Struan F. A., et al.
Publicado: (2020)

Type 1 diabetes defined by severe insulin deficiency occurs after 30 years of age and is commonly treated as type 2 diabetes
por: Thomas, Nicholas J., et al.
Publicado: (2019)

Rare Genetic Variants of Large Effect Influence Risk of Type 1 Diabetes
por: Forgetta, Vincenzo, et al.
Publicado: (2020)

Assessing the Combined Impact of 18 Common Genetic Variants of Modest Effect Sizes on Type 2 Diabetes Risk
por: Lango, Hana, et al.
Publicado: (2008)

Genetics of Childhood Obesity
por: Zhao, Jianhua, et al.
Publicado: (2011)

Allelic Expression Imbalance: Tipping the Scales to Elucidate the Function of Type 2 Diabetes–Associated Loci
por: McCormack, Shana E., et al.
Publicado: (2015)

Dietary and genetic risk scores and incidence of type 2 diabetes
por: Ericson, Ulrika, et al.
Publicado: (2018)

Use of Net Reclassification Improvement (NRI) Method Confirms The Utility of Combined Genetic Risk Score to Predict Type 2 Diabetes
por: Tam, Claudia H. T., et al.
Publicado: (2013)

Association Analysis of Type 2 Diabetes Loci in Type 1 Diabetes
por: Qu, Hui-Qi, et al.
Publicado: (2008)

Relative contribution of type 1 and type 2 diabetes loci to the genetic etiology of adult-onset, non-insulin-requiring autoimmune diabetes
por: Mishra, Rajashree, et al.
Publicado: (2017)

Genetics and epigenetics in the obesity phenotyping scenario
por: Trang, Khanh, et al.
Publicado: (2023)

The genetics of human obesity
por: Xia, Qianghua, et al.
Publicado: (2013)

Personalized risk prediction for type 2 diabetes: the potential of genetic risk scores
por: Läll, Kristi, et al.
Publicado: (2017)

Genetic Risk Score in Diabetes Associated With Chronic Pancreatitis Versus Type 2 Diabetes Mellitus
por: Goodarzi, Mark O., et al.
Publicado: (2019)

Clinical validity and utility of genetic risk scores in prostate cancer
por: Helfand, Brian T, et al.
Publicado: (2016)

Genetic risk score for risk prediction of diabetic nephropathy in Han Chinese type 2 diabetes patients
por: Liao, Li-Na, et al.
Publicado: (2019)

Assessing the clinical utility of genetic risk scores for targeted cancer screening
por: Conran, Carly A., et al.
Publicado: (2021)

The Genetic Architecture of Type 1 Diabetes
por: Jerram, Samuel T., et al.
Publicado: (2017)

Genetic architecture of type 1 diabetes with low genetic risk score informed by 41 unreported loci
por: Qu, Hui-Qi, et al.
Publicado: (2021)

Identification and analysis of individuals who deviate from their genetically-predicted phenotype
por: Hawkes, Gareth, et al.
Publicado: (2023)

Identification and analysis of individuals who deviate from their genetically-predicted phenotype
por: Hawkes, Gareth, et al.
Publicado: (2023)

A Genetic Risk Score Improves the Prediction of Type 2 Diabetes Mellitus in Mexican Youths but Has Lower Predictive Utility Compared With Non-Genetic Factors
por: Miranda-Lora, América Liliana, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_qk22ste3v7kmp1p1a7s45p0ck8