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The emerging role of extracellular vesicles in fungi: a double-edged sword

Fungi are eukaryotic microorganisms found in nature, which can invade the human body and cause tissue damage, inflammatory reactions, organ dysfunctions, and diseases. These diseases can severely damage the patient’s body systems and functions, leading to a range of clinical symptoms that can be lif...

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Autores principales: Lai, Yi, Jiang, Bowei, Hou, Fangpeng, Huang, Xinhong, Ling, Baodian, Lu, Hongfei, Zhong, Tianyu, Huang, Junyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10390730/
https://www.ncbi.nlm.nih.gov/pubmed/37533824
http://dx.doi.org/10.3389/fmicb.2023.1216895
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author Lai, Yi
Jiang, Bowei
Hou, Fangpeng
Huang, Xinhong
Ling, Baodian
Lu, Hongfei
Zhong, Tianyu
Huang, Junyun
author_facet Lai, Yi
Jiang, Bowei
Hou, Fangpeng
Huang, Xinhong
Ling, Baodian
Lu, Hongfei
Zhong, Tianyu
Huang, Junyun
author_sort Lai, Yi
collection PubMed
description Fungi are eukaryotic microorganisms found in nature, which can invade the human body and cause tissue damage, inflammatory reactions, organ dysfunctions, and diseases. These diseases can severely damage the patient’s body systems and functions, leading to a range of clinical symptoms that can be life-threatening. As the incidence of invasive fungal infections has progressively increased in the recent years, a wealth of evidence has confirmed the “double-edged sword” role of fungal extracellular vesicles (EVs) in intercellular communication and pathogen-host interactions. Fungal EVs act as mediators of cellular communication, affecting fungal-host cell interactions, delivering virulence factors, and promoting infection. Fungal EVs can also have an induced protective effect, affecting fungal growth and stimulating adaptive immune responses. By integrating recent studies, we discuss the role of EVs in fungi, providing strong theoretical support for the early prevention and treatment of invasive fungal infections. Finally, we highlight the feasibility of using fungal EVs as drug carriers and in vaccine development.
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spelling pubmed-103907302023-08-02 The emerging role of extracellular vesicles in fungi: a double-edged sword Lai, Yi Jiang, Bowei Hou, Fangpeng Huang, Xinhong Ling, Baodian Lu, Hongfei Zhong, Tianyu Huang, Junyun Front Microbiol Microbiology Fungi are eukaryotic microorganisms found in nature, which can invade the human body and cause tissue damage, inflammatory reactions, organ dysfunctions, and diseases. These diseases can severely damage the patient’s body systems and functions, leading to a range of clinical symptoms that can be life-threatening. As the incidence of invasive fungal infections has progressively increased in the recent years, a wealth of evidence has confirmed the “double-edged sword” role of fungal extracellular vesicles (EVs) in intercellular communication and pathogen-host interactions. Fungal EVs act as mediators of cellular communication, affecting fungal-host cell interactions, delivering virulence factors, and promoting infection. Fungal EVs can also have an induced protective effect, affecting fungal growth and stimulating adaptive immune responses. By integrating recent studies, we discuss the role of EVs in fungi, providing strong theoretical support for the early prevention and treatment of invasive fungal infections. Finally, we highlight the feasibility of using fungal EVs as drug carriers and in vaccine development. Frontiers Media S.A. 2023-07-18 /pmc/articles/PMC10390730/ /pubmed/37533824 http://dx.doi.org/10.3389/fmicb.2023.1216895 Text en Copyright © 2023 Lai, Jiang, Hou, Huang, Ling, Lu, Zhong and Huang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Lai, Yi
Jiang, Bowei
Hou, Fangpeng
Huang, Xinhong
Ling, Baodian
Lu, Hongfei
Zhong, Tianyu
Huang, Junyun
The emerging role of extracellular vesicles in fungi: a double-edged sword
title The emerging role of extracellular vesicles in fungi: a double-edged sword
title_full The emerging role of extracellular vesicles in fungi: a double-edged sword
title_fullStr The emerging role of extracellular vesicles in fungi: a double-edged sword
title_full_unstemmed The emerging role of extracellular vesicles in fungi: a double-edged sword
title_short The emerging role of extracellular vesicles in fungi: a double-edged sword
title_sort emerging role of extracellular vesicles in fungi: a double-edged sword
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10390730/
https://www.ncbi.nlm.nih.gov/pubmed/37533824
http://dx.doi.org/10.3389/fmicb.2023.1216895
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