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Current evidence, clinical applications, and future directions of transcranial magnetic stimulation as a treatment for ischemic stroke

Transcranial magnetic stimulation (TMS) is a non-invasive brain neurostimulation technique that can be used as one of the adjunctive treatment techniques for neurological recovery after stroke. Animal studies have shown that TMS treatment of rats with middle cerebral artery occlusion (MCAO) model re...

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Autores principales: Zhou, Li, Jin, Yaju, Wu, Danli, Cun, Yongdan, Zhang, Chengcai, Peng, Yicheng, Chen, Na, Yang, Xichen, Zhang, Simei, Ning, Rong, Kuang, Peng, Wang, Zuhong, Zhang, Pengyue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10390744/
https://www.ncbi.nlm.nih.gov/pubmed/37534033
http://dx.doi.org/10.3389/fnins.2023.1177283
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author Zhou, Li
Jin, Yaju
Wu, Danli
Cun, Yongdan
Zhang, Chengcai
Peng, Yicheng
Chen, Na
Yang, Xichen
Zhang, Simei
Ning, Rong
Kuang, Peng
Wang, Zuhong
Zhang, Pengyue
author_facet Zhou, Li
Jin, Yaju
Wu, Danli
Cun, Yongdan
Zhang, Chengcai
Peng, Yicheng
Chen, Na
Yang, Xichen
Zhang, Simei
Ning, Rong
Kuang, Peng
Wang, Zuhong
Zhang, Pengyue
author_sort Zhou, Li
collection PubMed
description Transcranial magnetic stimulation (TMS) is a non-invasive brain neurostimulation technique that can be used as one of the adjunctive treatment techniques for neurological recovery after stroke. Animal studies have shown that TMS treatment of rats with middle cerebral artery occlusion (MCAO) model reduced cerebral infarct volume and improved neurological dysfunction in model rats. In addition, clinical case reports have also shown that TMS treatment has positive neuroprotective effects in stroke patients, improving a variety of post-stroke neurological deficits such as motor function, swallowing, cognitive function, speech function, central post-stroke pain, spasticity, and other post-stroke sequelae. However, even though numerous studies have shown a neuroprotective effect of TMS in stroke patients, its possible neuroprotective mechanism is not clear. Therefore, in this review, we describe the potential mechanisms of TMS to improve neurological function in terms of neurogenesis, angiogenesis, anti-inflammation, antioxidant, and anti-apoptosis, and provide insight into the current clinical application of TMS in multiple neurological dysfunctions in stroke. Finally, some of the current challenges faced by TMS are summarized and some suggestions for its future research directions are made.
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spelling pubmed-103907442023-08-02 Current evidence, clinical applications, and future directions of transcranial magnetic stimulation as a treatment for ischemic stroke Zhou, Li Jin, Yaju Wu, Danli Cun, Yongdan Zhang, Chengcai Peng, Yicheng Chen, Na Yang, Xichen Zhang, Simei Ning, Rong Kuang, Peng Wang, Zuhong Zhang, Pengyue Front Neurosci Neuroscience Transcranial magnetic stimulation (TMS) is a non-invasive brain neurostimulation technique that can be used as one of the adjunctive treatment techniques for neurological recovery after stroke. Animal studies have shown that TMS treatment of rats with middle cerebral artery occlusion (MCAO) model reduced cerebral infarct volume and improved neurological dysfunction in model rats. In addition, clinical case reports have also shown that TMS treatment has positive neuroprotective effects in stroke patients, improving a variety of post-stroke neurological deficits such as motor function, swallowing, cognitive function, speech function, central post-stroke pain, spasticity, and other post-stroke sequelae. However, even though numerous studies have shown a neuroprotective effect of TMS in stroke patients, its possible neuroprotective mechanism is not clear. Therefore, in this review, we describe the potential mechanisms of TMS to improve neurological function in terms of neurogenesis, angiogenesis, anti-inflammation, antioxidant, and anti-apoptosis, and provide insight into the current clinical application of TMS in multiple neurological dysfunctions in stroke. Finally, some of the current challenges faced by TMS are summarized and some suggestions for its future research directions are made. Frontiers Media S.A. 2023-07-18 /pmc/articles/PMC10390744/ /pubmed/37534033 http://dx.doi.org/10.3389/fnins.2023.1177283 Text en Copyright © 2023 Zhou, Jin, Wu, Cun, Zhang, Peng, Chen, Yang, Zhang, Ning, Kuang, Wang and Zhang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Zhou, Li
Jin, Yaju
Wu, Danli
Cun, Yongdan
Zhang, Chengcai
Peng, Yicheng
Chen, Na
Yang, Xichen
Zhang, Simei
Ning, Rong
Kuang, Peng
Wang, Zuhong
Zhang, Pengyue
Current evidence, clinical applications, and future directions of transcranial magnetic stimulation as a treatment for ischemic stroke
title Current evidence, clinical applications, and future directions of transcranial magnetic stimulation as a treatment for ischemic stroke
title_full Current evidence, clinical applications, and future directions of transcranial magnetic stimulation as a treatment for ischemic stroke
title_fullStr Current evidence, clinical applications, and future directions of transcranial magnetic stimulation as a treatment for ischemic stroke
title_full_unstemmed Current evidence, clinical applications, and future directions of transcranial magnetic stimulation as a treatment for ischemic stroke
title_short Current evidence, clinical applications, and future directions of transcranial magnetic stimulation as a treatment for ischemic stroke
title_sort current evidence, clinical applications, and future directions of transcranial magnetic stimulation as a treatment for ischemic stroke
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10390744/
https://www.ncbi.nlm.nih.gov/pubmed/37534033
http://dx.doi.org/10.3389/fnins.2023.1177283
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