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APR-246 Enhances Colorectal Cancer Sensitivity to Radiotherapy

p53 mutation is common and highly related to radiotherapy resistance in rectal cancer. APR-246, as a small molecule, can restore the tumor-suppressor function to mutant p53. As there is currently no existing study on combining APR-246 with radiation in rectal cancer, our objective was to investigate...

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Detalles Bibliográficos
Autores principales:	Xie, Xuqin, Fan, Chuanwen, Luo, Bin, Zhang, Jing, Jensen, Lasse D., Burman, Jonas, Jönsson, Carolin, Ljusberg, Anna, Larsson, Peter, Zhao, Zengren, Sun, Xiao-Feng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for Cancer Research 2023
Materias:	Small Molecule Therapeutics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10390889/ https://www.ncbi.nlm.nih.gov/pubmed/37216282 http://dx.doi.org/10.1158/1535-7163.MCT-22-0275

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