NF-kB’s contribution to B cell fate decisions

NF-κB signaling is essential to an effective innate and adaptive immune response. Many immune-specific functional and developmental outcomes depend in large on NF-κB. The formidable task of sorting out the mechanisms behind the regulation and outcome of NF-κB signaling remains an important area of i...

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Autores principales: Guldenpfennig, Caitlyn, Teixeiro, Emma, Daniels, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10391175/
https://www.ncbi.nlm.nih.gov/pubmed/37533858
http://dx.doi.org/10.3389/fimmu.2023.1214095
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author Guldenpfennig, Caitlyn
Teixeiro, Emma
Daniels, Mark
author_facet Guldenpfennig, Caitlyn
Teixeiro, Emma
Daniels, Mark
author_sort Guldenpfennig, Caitlyn
collection PubMed
description NF-κB signaling is essential to an effective innate and adaptive immune response. Many immune-specific functional and developmental outcomes depend in large on NF-κB. The formidable task of sorting out the mechanisms behind the regulation and outcome of NF-κB signaling remains an important area of immunology research. Here we briefly discuss the role of NF-κB in regulating cell fate decisions at various times in the path of B cell development, activation, and the generation of long-term humoral immunity.
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spelling pubmed-103911752023-08-02 NF-kB’s contribution to B cell fate decisions Guldenpfennig, Caitlyn Teixeiro, Emma Daniels, Mark Front Immunol Immunology NF-κB signaling is essential to an effective innate and adaptive immune response. Many immune-specific functional and developmental outcomes depend in large on NF-κB. The formidable task of sorting out the mechanisms behind the regulation and outcome of NF-κB signaling remains an important area of immunology research. Here we briefly discuss the role of NF-κB in regulating cell fate decisions at various times in the path of B cell development, activation, and the generation of long-term humoral immunity. Frontiers Media S.A. 2023-07-18 /pmc/articles/PMC10391175/ /pubmed/37533858 http://dx.doi.org/10.3389/fimmu.2023.1214095 Text en Copyright © 2023 Guldenpfennig, Teixeiro and Daniels https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Guldenpfennig, Caitlyn
Teixeiro, Emma
Daniels, Mark
NF-kB’s contribution to B cell fate decisions
title NF-kB’s contribution to B cell fate decisions
title_full NF-kB’s contribution to B cell fate decisions
title_fullStr NF-kB’s contribution to B cell fate decisions
title_full_unstemmed NF-kB’s contribution to B cell fate decisions
title_short NF-kB’s contribution to B cell fate decisions
title_sort nf-kb’s contribution to b cell fate decisions
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10391175/
https://www.ncbi.nlm.nih.gov/pubmed/37533858
http://dx.doi.org/10.3389/fimmu.2023.1214095
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