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A Genetic Locus within the FMN1/GREM1 Gene Region Interacts with Body Mass Index in Colorectal Cancer Risk
Colorectal cancer risk can be impacted by genetic, environmental, and lifestyle factors, including diet and obesity. Gene-environment interactions (G × E) can provide biological insights into the effects of obesity on colorectal cancer risk. Here, we assessed potential genome-wide G × E interactions...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Association for Cancer Research
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10391330/ https://www.ncbi.nlm.nih.gov/pubmed/37249599 http://dx.doi.org/10.1158/0008-5472.CAN-22-3713 |
| _version_ | 1785082683039154176 |
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| author | Aglago, Elom K. Kim, Andre Lin, Yi Qu, Conghui Evangelou, Marina Ren, Yu Morrison, John Albanes, Demetrius Arndt, Volker Barry, Elizabeth L. Baurley, James W. Berndt, Sonja I. Bien, Stephanie A. Bishop, D. Timothy Bouras, Emmanouil Brenner, Hermann Buchanan, Daniel D. Budiarto, Arif Carreras-Torres, Robert Casey, Graham Cenggoro, Tjeng Wawan Chan, Andrew T. Chang-Claude, Jenny Chen, Xuechen Conti, David V. Devall, Matthew Diez-Obrero, Virginia Dimou, Niki Drew, David Figueiredo, Jane C. Gallinger, Steven Giles, Graham G. Gruber, Stephen B. Gsur, Andrea Gunter, Marc J. Hampel, Heather Harlid, Sophia Hidaka, Akihisa Harrison, Tabitha A. Hoffmeister, Michael Huyghe, Jeroen R. Jenkins, Mark A. Jordahl, Kristina Joshi, Amit D. Kawaguchi, Eric S. Keku, Temitope O. Kundaje, Anshul Larsson, Susanna C. Marchand, Loic Le Lewinger, Juan Pablo Li, Li Lynch, Brigid M. Mahesworo, Bharuno Mandic, Marko Obón-Santacana, Mireia Moreno, Victor Murphy, Neil Nan, Hongmei Nassir, Rami Newcomb, Polly A. Ogino, Shuji Ose, Jennifer Pai, Rish K. Palmer, Julie R. Papadimitriou, Nikos Pardamean, Bens Peoples, Anita R. Platz, Elizabeth A. Potter, John D. Prentice, Ross L. Rennert, Gad Ruiz-Narvaez, Edward Sakoda, Lori C. Scacheri, Peter C. Schmit, Stephanie L. Schoen, Robert E. Shcherbina, Anna Slattery, Martha L. Stern, Mariana C. Su, Yu-Ru Tangen, Catherine M. Thibodeau, Stephen N. Thomas, Duncan C. Tian, Yu Ulrich, Cornelia M. van Duijnhoven, Franzel JB Van Guelpen, Bethany Visvanathan, Kala Vodicka, Pavel Wang, Jun White, Emily Wolk, Alicja Woods, Michael O. Wu, Anna H. Zemlianskaia, Natalia Hsu, Li Gauderman, W. James Peters, Ulrike Tsilidis, Konstantinos K. Campbell, Peter T. |
| author_facet | Aglago, Elom K. Kim, Andre Lin, Yi Qu, Conghui Evangelou, Marina Ren, Yu Morrison, John Albanes, Demetrius Arndt, Volker Barry, Elizabeth L. Baurley, James W. Berndt, Sonja I. Bien, Stephanie A. Bishop, D. Timothy Bouras, Emmanouil Brenner, Hermann Buchanan, Daniel D. Budiarto, Arif Carreras-Torres, Robert Casey, Graham Cenggoro, Tjeng Wawan Chan, Andrew T. Chang-Claude, Jenny Chen, Xuechen Conti, David V. Devall, Matthew Diez-Obrero, Virginia Dimou, Niki Drew, David Figueiredo, Jane C. Gallinger, Steven Giles, Graham G. Gruber, Stephen B. Gsur, Andrea Gunter, Marc J. Hampel, Heather Harlid, Sophia Hidaka, Akihisa Harrison, Tabitha A. Hoffmeister, Michael Huyghe, Jeroen R. Jenkins, Mark A. Jordahl, Kristina Joshi, Amit D. Kawaguchi, Eric S. Keku, Temitope O. Kundaje, Anshul Larsson, Susanna C. Marchand, Loic Le Lewinger, Juan Pablo Li, Li Lynch, Brigid M. Mahesworo, Bharuno Mandic, Marko Obón-Santacana, Mireia Moreno, Victor Murphy, Neil Nan, Hongmei Nassir, Rami Newcomb, Polly A. Ogino, Shuji Ose, Jennifer Pai, Rish K. Palmer, Julie R. Papadimitriou, Nikos Pardamean, Bens Peoples, Anita R. Platz, Elizabeth A. Potter, John D. Prentice, Ross L. Rennert, Gad Ruiz-Narvaez, Edward Sakoda, Lori C. Scacheri, Peter C. Schmit, Stephanie L. Schoen, Robert E. Shcherbina, Anna Slattery, Martha L. Stern, Mariana C. Su, Yu-Ru Tangen, Catherine M. Thibodeau, Stephen N. Thomas, Duncan C. Tian, Yu Ulrich, Cornelia M. van Duijnhoven, Franzel JB Van Guelpen, Bethany Visvanathan, Kala Vodicka, Pavel Wang, Jun White, Emily Wolk, Alicja Woods, Michael O. Wu, Anna H. Zemlianskaia, Natalia Hsu, Li Gauderman, W. James Peters, Ulrike Tsilidis, Konstantinos K. Campbell, Peter T. |
| author_sort | Aglago, Elom K. |
| collection | PubMed |
| description | Colorectal cancer risk can be impacted by genetic, environmental, and lifestyle factors, including diet and obesity. Gene-environment interactions (G × E) can provide biological insights into the effects of obesity on colorectal cancer risk. Here, we assessed potential genome-wide G × E interactions between body mass index (BMI) and common SNPs for colorectal cancer risk using data from 36,415 colorectal cancer cases and 48,451 controls from three international colorectal cancer consortia (CCFR, CORECT, and GECCO). The G × E tests included the conventional logistic regression using multiplicative terms (one degree of freedom, 1DF test), the two-step EDGE method, and the joint 3DF test, each of which is powerful for detecting G × E interactions under specific conditions. BMI was associated with higher colorectal cancer risk. The two-step approach revealed a statistically significant G×BMI interaction located within the Formin 1/Gremlin 1 (FMN1/GREM1) gene region (rs58349661). This SNP was also identified by the 3DF test, with a suggestive statistical significance in the 1DF test. Among participants with the CC genotype of rs58349661, overweight and obesity categories were associated with higher colorectal cancer risk, whereas null associations were observed across BMI categories in those with the TT genotype. Using data from three large international consortia, this study discovered a locus in the FMN1/GREM1 gene region that interacts with BMI on the association with colorectal cancer risk. Further studies should examine the potential mechanisms through which this locus modifies the etiologic link between obesity and colorectal cancer. SIGNIFICANCE: This gene-environment interaction analysis revealed a genetic locus in FMN1/GREM1 that interacts with body mass index in colorectal cancer risk, suggesting potential implications for precision prevention strategies. |
| format | Online Article Text |
| id | pubmed-10391330 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2023 |
| publisher | American Association for Cancer Research |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-103913302023-08-02 A Genetic Locus within the FMN1/GREM1 Gene Region Interacts with Body Mass Index in Colorectal Cancer Risk Aglago, Elom K. Kim, Andre Lin, Yi Qu, Conghui Evangelou, Marina Ren, Yu Morrison, John Albanes, Demetrius Arndt, Volker Barry, Elizabeth L. Baurley, James W. Berndt, Sonja I. Bien, Stephanie A. Bishop, D. Timothy Bouras, Emmanouil Brenner, Hermann Buchanan, Daniel D. Budiarto, Arif Carreras-Torres, Robert Casey, Graham Cenggoro, Tjeng Wawan Chan, Andrew T. Chang-Claude, Jenny Chen, Xuechen Conti, David V. Devall, Matthew Diez-Obrero, Virginia Dimou, Niki Drew, David Figueiredo, Jane C. Gallinger, Steven Giles, Graham G. Gruber, Stephen B. Gsur, Andrea Gunter, Marc J. Hampel, Heather Harlid, Sophia Hidaka, Akihisa Harrison, Tabitha A. Hoffmeister, Michael Huyghe, Jeroen R. Jenkins, Mark A. Jordahl, Kristina Joshi, Amit D. Kawaguchi, Eric S. Keku, Temitope O. Kundaje, Anshul Larsson, Susanna C. Marchand, Loic Le Lewinger, Juan Pablo Li, Li Lynch, Brigid M. Mahesworo, Bharuno Mandic, Marko Obón-Santacana, Mireia Moreno, Victor Murphy, Neil Nan, Hongmei Nassir, Rami Newcomb, Polly A. Ogino, Shuji Ose, Jennifer Pai, Rish K. Palmer, Julie R. Papadimitriou, Nikos Pardamean, Bens Peoples, Anita R. Platz, Elizabeth A. Potter, John D. Prentice, Ross L. Rennert, Gad Ruiz-Narvaez, Edward Sakoda, Lori C. Scacheri, Peter C. Schmit, Stephanie L. Schoen, Robert E. Shcherbina, Anna Slattery, Martha L. Stern, Mariana C. Su, Yu-Ru Tangen, Catherine M. Thibodeau, Stephen N. Thomas, Duncan C. Tian, Yu Ulrich, Cornelia M. van Duijnhoven, Franzel JB Van Guelpen, Bethany Visvanathan, Kala Vodicka, Pavel Wang, Jun White, Emily Wolk, Alicja Woods, Michael O. Wu, Anna H. Zemlianskaia, Natalia Hsu, Li Gauderman, W. James Peters, Ulrike Tsilidis, Konstantinos K. Campbell, Peter T. Cancer Res Translational Cancer Biology Colorectal cancer risk can be impacted by genetic, environmental, and lifestyle factors, including diet and obesity. Gene-environment interactions (G × E) can provide biological insights into the effects of obesity on colorectal cancer risk. Here, we assessed potential genome-wide G × E interactions between body mass index (BMI) and common SNPs for colorectal cancer risk using data from 36,415 colorectal cancer cases and 48,451 controls from three international colorectal cancer consortia (CCFR, CORECT, and GECCO). The G × E tests included the conventional logistic regression using multiplicative terms (one degree of freedom, 1DF test), the two-step EDGE method, and the joint 3DF test, each of which is powerful for detecting G × E interactions under specific conditions. BMI was associated with higher colorectal cancer risk. The two-step approach revealed a statistically significant G×BMI interaction located within the Formin 1/Gremlin 1 (FMN1/GREM1) gene region (rs58349661). This SNP was also identified by the 3DF test, with a suggestive statistical significance in the 1DF test. Among participants with the CC genotype of rs58349661, overweight and obesity categories were associated with higher colorectal cancer risk, whereas null associations were observed across BMI categories in those with the TT genotype. Using data from three large international consortia, this study discovered a locus in the FMN1/GREM1 gene region that interacts with BMI on the association with colorectal cancer risk. Further studies should examine the potential mechanisms through which this locus modifies the etiologic link between obesity and colorectal cancer. SIGNIFICANCE: This gene-environment interaction analysis revealed a genetic locus in FMN1/GREM1 that interacts with body mass index in colorectal cancer risk, suggesting potential implications for precision prevention strategies. American Association for Cancer Research 2023-08-01 2023-05-30 /pmc/articles/PMC10391330/ /pubmed/37249599 http://dx.doi.org/10.1158/0008-5472.CAN-22-3713 Text en ©2023 The Authors; Published by the American Association for Cancer Research https://creativecommons.org/licenses/by/4.0/This open access article is distributed under the Creative Commons Attribution 4.0 International (CC BY 4.0) license. |
| spellingShingle | Translational Cancer Biology Aglago, Elom K. Kim, Andre Lin, Yi Qu, Conghui Evangelou, Marina Ren, Yu Morrison, John Albanes, Demetrius Arndt, Volker Barry, Elizabeth L. Baurley, James W. Berndt, Sonja I. Bien, Stephanie A. Bishop, D. Timothy Bouras, Emmanouil Brenner, Hermann Buchanan, Daniel D. Budiarto, Arif Carreras-Torres, Robert Casey, Graham Cenggoro, Tjeng Wawan Chan, Andrew T. Chang-Claude, Jenny Chen, Xuechen Conti, David V. Devall, Matthew Diez-Obrero, Virginia Dimou, Niki Drew, David Figueiredo, Jane C. Gallinger, Steven Giles, Graham G. Gruber, Stephen B. Gsur, Andrea Gunter, Marc J. Hampel, Heather Harlid, Sophia Hidaka, Akihisa Harrison, Tabitha A. Hoffmeister, Michael Huyghe, Jeroen R. Jenkins, Mark A. Jordahl, Kristina Joshi, Amit D. Kawaguchi, Eric S. Keku, Temitope O. Kundaje, Anshul Larsson, Susanna C. Marchand, Loic Le Lewinger, Juan Pablo Li, Li Lynch, Brigid M. Mahesworo, Bharuno Mandic, Marko Obón-Santacana, Mireia Moreno, Victor Murphy, Neil Nan, Hongmei Nassir, Rami Newcomb, Polly A. Ogino, Shuji Ose, Jennifer Pai, Rish K. Palmer, Julie R. Papadimitriou, Nikos Pardamean, Bens Peoples, Anita R. Platz, Elizabeth A. Potter, John D. Prentice, Ross L. Rennert, Gad Ruiz-Narvaez, Edward Sakoda, Lori C. Scacheri, Peter C. Schmit, Stephanie L. Schoen, Robert E. Shcherbina, Anna Slattery, Martha L. Stern, Mariana C. Su, Yu-Ru Tangen, Catherine M. Thibodeau, Stephen N. Thomas, Duncan C. Tian, Yu Ulrich, Cornelia M. van Duijnhoven, Franzel JB Van Guelpen, Bethany Visvanathan, Kala Vodicka, Pavel Wang, Jun White, Emily Wolk, Alicja Woods, Michael O. Wu, Anna H. Zemlianskaia, Natalia Hsu, Li Gauderman, W. James Peters, Ulrike Tsilidis, Konstantinos K. Campbell, Peter T. A Genetic Locus within the FMN1/GREM1 Gene Region Interacts with Body Mass Index in Colorectal Cancer Risk |
| title | A Genetic Locus within the FMN1/GREM1 Gene Region Interacts with Body Mass Index in Colorectal Cancer Risk |
| title_full | A Genetic Locus within the FMN1/GREM1 Gene Region Interacts with Body Mass Index in Colorectal Cancer Risk |
| title_fullStr | A Genetic Locus within the FMN1/GREM1 Gene Region Interacts with Body Mass Index in Colorectal Cancer Risk |
| title_full_unstemmed | A Genetic Locus within the FMN1/GREM1 Gene Region Interacts with Body Mass Index in Colorectal Cancer Risk |
| title_short | A Genetic Locus within the FMN1/GREM1 Gene Region Interacts with Body Mass Index in Colorectal Cancer Risk |
| title_sort | genetic locus within the fmn1/grem1 gene region interacts with body mass index in colorectal cancer risk |
| topic | Translational Cancer Biology |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10391330/ https://www.ncbi.nlm.nih.gov/pubmed/37249599 http://dx.doi.org/10.1158/0008-5472.CAN-22-3713 |
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geneticlocuswithinthefmn1grem1generegioninteractswithbodymassindexincolorectalcancerrisk AT barryelizabethl geneticlocuswithinthefmn1grem1generegioninteractswithbodymassindexincolorectalcancerrisk AT baurleyjamesw geneticlocuswithinthefmn1grem1generegioninteractswithbodymassindexincolorectalcancerrisk AT berndtsonjai geneticlocuswithinthefmn1grem1generegioninteractswithbodymassindexincolorectalcancerrisk AT bienstephaniea geneticlocuswithinthefmn1grem1generegioninteractswithbodymassindexincolorectalcancerrisk AT bishopdtimothy geneticlocuswithinthefmn1grem1generegioninteractswithbodymassindexincolorectalcancerrisk AT bourasemmanouil geneticlocuswithinthefmn1grem1generegioninteractswithbodymassindexincolorectalcancerrisk AT brennerhermann geneticlocuswithinthefmn1grem1generegioninteractswithbodymassindexincolorectalcancerrisk AT buchanandanield geneticlocuswithinthefmn1grem1generegioninteractswithbodymassindexincolorectalcancerrisk AT budiartoarif geneticlocuswithinthefmn1grem1generegioninteractswithbodymassindexincolorectalcancerrisk AT carrerastorresrobert geneticlocuswithinthefmn1grem1generegioninteractswithbodymassindexincolorectalcancerrisk AT caseygraham geneticlocuswithinthefmn1grem1generegioninteractswithbodymassindexincolorectalcancerrisk AT cenggorotjengwawan geneticlocuswithinthefmn1grem1generegioninteractswithbodymassindexincolorectalcancerrisk AT chanandrewt geneticlocuswithinthefmn1grem1generegioninteractswithbodymassindexincolorectalcancerrisk AT changclaudejenny geneticlocuswithinthefmn1grem1generegioninteractswithbodymassindexincolorectalcancerrisk AT chenxuechen geneticlocuswithinthefmn1grem1generegioninteractswithbodymassindexincolorectalcancerrisk AT contidavidv geneticlocuswithinthefmn1grem1generegioninteractswithbodymassindexincolorectalcancerrisk AT devallmatthew geneticlocuswithinthefmn1grem1generegioninteractswithbodymassindexincolorectalcancerrisk AT diezobrerovirginia geneticlocuswithinthefmn1grem1generegioninteractswithbodymassindexincolorectalcancerrisk AT dimouniki geneticlocuswithinthefmn1grem1generegioninteractswithbodymassindexincolorectalcancerrisk AT drewdavid geneticlocuswithinthefmn1grem1generegioninteractswithbodymassindexincolorectalcancerrisk AT figueiredojanec geneticlocuswithinthefmn1grem1generegioninteractswithbodymassindexincolorectalcancerrisk AT gallingersteven geneticlocuswithinthefmn1grem1generegioninteractswithbodymassindexincolorectalcancerrisk AT gilesgrahamg geneticlocuswithinthefmn1grem1generegioninteractswithbodymassindexincolorectalcancerrisk AT gruberstephenb geneticlocuswithinthefmn1grem1generegioninteractswithbodymassindexincolorectalcancerrisk AT gsurandrea geneticlocuswithinthefmn1grem1generegioninteractswithbodymassindexincolorectalcancerrisk AT guntermarcj geneticlocuswithinthefmn1grem1generegioninteractswithbodymassindexincolorectalcancerrisk AT hampelheather geneticlocuswithinthefmn1grem1generegioninteractswithbodymassindexincolorectalcancerrisk AT harlidsophia geneticlocuswithinthefmn1grem1generegioninteractswithbodymassindexincolorectalcancerrisk AT hidakaakihisa geneticlocuswithinthefmn1grem1generegioninteractswithbodymassindexincolorectalcancerrisk AT harrisontabithaa geneticlocuswithinthefmn1grem1generegioninteractswithbodymassindexincolorectalcancerrisk AT hoffmeistermichael geneticlocuswithinthefmn1grem1generegioninteractswithbodymassindexincolorectalcancerrisk AT huyghejeroenr geneticlocuswithinthefmn1grem1generegioninteractswithbodymassindexincolorectalcancerrisk AT jenkinsmarka geneticlocuswithinthefmn1grem1generegioninteractswithbodymassindexincolorectalcancerrisk AT jordahlkristina geneticlocuswithinthefmn1grem1generegioninteractswithbodymassindexincolorectalcancerrisk AT joshiamitd geneticlocuswithinthefmn1grem1generegioninteractswithbodymassindexincolorectalcancerrisk AT kawaguchierics geneticlocuswithinthefmn1grem1generegioninteractswithbodymassindexincolorectalcancerrisk AT kekutemitopeo geneticlocuswithinthefmn1grem1generegioninteractswithbodymassindexincolorectalcancerrisk AT kundajeanshul geneticlocuswithinthefmn1grem1generegioninteractswithbodymassindexincolorectalcancerrisk AT larssonsusannac geneticlocuswithinthefmn1grem1generegioninteractswithbodymassindexincolorectalcancerrisk AT marchandloicle geneticlocuswithinthefmn1grem1generegioninteractswithbodymassindexincolorectalcancerrisk AT lewingerjuanpablo geneticlocuswithinthefmn1grem1generegioninteractswithbodymassindexincolorectalcancerrisk AT lili geneticlocuswithinthefmn1grem1generegioninteractswithbodymassindexincolorectalcancerrisk AT lynchbrigidm geneticlocuswithinthefmn1grem1generegioninteractswithbodymassindexincolorectalcancerrisk AT mahesworobharuno geneticlocuswithinthefmn1grem1generegioninteractswithbodymassindexincolorectalcancerrisk AT mandicmarko geneticlocuswithinthefmn1grem1generegioninteractswithbodymassindexincolorectalcancerrisk AT obonsantacanamireia geneticlocuswithinthefmn1grem1generegioninteractswithbodymassindexincolorectalcancerrisk AT morenovictor geneticlocuswithinthefmn1grem1generegioninteractswithbodymassindexincolorectalcancerrisk AT murphyneil geneticlocuswithinthefmn1grem1generegioninteractswithbodymassindexincolorectalcancerrisk AT nanhongmei geneticlocuswithinthefmn1grem1generegioninteractswithbodymassindexincolorectalcancerrisk AT nassirrami geneticlocuswithinthefmn1grem1generegioninteractswithbodymassindexincolorectalcancerrisk AT newcombpollya geneticlocuswithinthefmn1grem1generegioninteractswithbodymassindexincolorectalcancerrisk AT oginoshuji geneticlocuswithinthefmn1grem1generegioninteractswithbodymassindexincolorectalcancerrisk AT osejennifer geneticlocuswithinthefmn1grem1generegioninteractswithbodymassindexincolorectalcancerrisk AT pairishk geneticlocuswithinthefmn1grem1generegioninteractswithbodymassindexincolorectalcancerrisk AT palmerjulier geneticlocuswithinthefmn1grem1generegioninteractswithbodymassindexincolorectalcancerrisk AT papadimitriounikos geneticlocuswithinthefmn1grem1generegioninteractswithbodymassindexincolorectalcancerrisk AT pardameanbens geneticlocuswithinthefmn1grem1generegioninteractswithbodymassindexincolorectalcancerrisk AT peoplesanitar geneticlocuswithinthefmn1grem1generegioninteractswithbodymassindexincolorectalcancerrisk AT platzelizabetha geneticlocuswithinthefmn1grem1generegioninteractswithbodymassindexincolorectalcancerrisk AT potterjohnd geneticlocuswithinthefmn1grem1generegioninteractswithbodymassindexincolorectalcancerrisk AT prenticerossl geneticlocuswithinthefmn1grem1generegioninteractswithbodymassindexincolorectalcancerrisk AT rennertgad geneticlocuswithinthefmn1grem1generegioninteractswithbodymassindexincolorectalcancerrisk AT ruiznarvaezedward geneticlocuswithinthefmn1grem1generegioninteractswithbodymassindexincolorectalcancerrisk AT sakodaloric geneticlocuswithinthefmn1grem1generegioninteractswithbodymassindexincolorectalcancerrisk AT scacheripeterc geneticlocuswithinthefmn1grem1generegioninteractswithbodymassindexincolorectalcancerrisk AT schmitstephaniel geneticlocuswithinthefmn1grem1generegioninteractswithbodymassindexincolorectalcancerrisk AT schoenroberte geneticlocuswithinthefmn1grem1generegioninteractswithbodymassindexincolorectalcancerrisk AT shcherbinaanna geneticlocuswithinthefmn1grem1generegioninteractswithbodymassindexincolorectalcancerrisk AT slatterymarthal geneticlocuswithinthefmn1grem1generegioninteractswithbodymassindexincolorectalcancerrisk AT sternmarianac geneticlocuswithinthefmn1grem1generegioninteractswithbodymassindexincolorectalcancerrisk AT suyuru geneticlocuswithinthefmn1grem1generegioninteractswithbodymassindexincolorectalcancerrisk AT tangencatherinem geneticlocuswithinthefmn1grem1generegioninteractswithbodymassindexincolorectalcancerrisk AT thibodeaustephenn geneticlocuswithinthefmn1grem1generegioninteractswithbodymassindexincolorectalcancerrisk AT thomasduncanc geneticlocuswithinthefmn1grem1generegioninteractswithbodymassindexincolorectalcancerrisk AT tianyu geneticlocuswithinthefmn1grem1generegioninteractswithbodymassindexincolorectalcancerrisk AT ulrichcorneliam geneticlocuswithinthefmn1grem1generegioninteractswithbodymassindexincolorectalcancerrisk AT vanduijnhovenfranzeljb geneticlocuswithinthefmn1grem1generegioninteractswithbodymassindexincolorectalcancerrisk AT vanguelpenbethany geneticlocuswithinthefmn1grem1generegioninteractswithbodymassindexincolorectalcancerrisk AT visvanathankala geneticlocuswithinthefmn1grem1generegioninteractswithbodymassindexincolorectalcancerrisk AT vodickapavel geneticlocuswithinthefmn1grem1generegioninteractswithbodymassindexincolorectalcancerrisk AT wangjun geneticlocuswithinthefmn1grem1generegioninteractswithbodymassindexincolorectalcancerrisk AT whiteemily geneticlocuswithinthefmn1grem1generegioninteractswithbodymassindexincolorectalcancerrisk AT wolkalicja geneticlocuswithinthefmn1grem1generegioninteractswithbodymassindexincolorectalcancerrisk AT woodsmichaelo geneticlocuswithinthefmn1grem1generegioninteractswithbodymassindexincolorectalcancerrisk AT wuannah geneticlocuswithinthefmn1grem1generegioninteractswithbodymassindexincolorectalcancerrisk AT zemlianskaianatalia geneticlocuswithinthefmn1grem1generegioninteractswithbodymassindexincolorectalcancerrisk AT hsuli geneticlocuswithinthefmn1grem1generegioninteractswithbodymassindexincolorectalcancerrisk AT gaudermanwjames geneticlocuswithinthefmn1grem1generegioninteractswithbodymassindexincolorectalcancerrisk AT petersulrike geneticlocuswithinthefmn1grem1generegioninteractswithbodymassindexincolorectalcancerrisk AT tsilidiskonstantinosk geneticlocuswithinthefmn1grem1generegioninteractswithbodymassindexincolorectalcancerrisk AT campbellpetert geneticlocuswithinthefmn1grem1generegioninteractswithbodymassindexincolorectalcancerrisk |