Immunopathogenesis of corneal graft rejection

The most common cause of corneal graft failure is corneal graft rejection (CGR). Although cornea is one of the immune-privileged sites, it can still get a rejection episode due to a breach in its natural protective mechanism. Both anatomical and structural properties of cornea and anterior chamber c...

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Autores principales: Maharana, Prafulla Kumar, Mandal, Sohini, Kaweri, Luci, Sahay, Pranita, Lata, Suman, Asif, Mohamed Ibrahime, Nagpal, Ritu, Sharma, Namrata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2023
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10391393/
https://www.ncbi.nlm.nih.gov/pubmed/37203024
http://dx.doi.org/10.4103/IJO.IJO_2866_22
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author Maharana, Prafulla Kumar
Mandal, Sohini
Kaweri, Luci
Sahay, Pranita
Lata, Suman
Asif, Mohamed Ibrahime
Nagpal, Ritu
Sharma, Namrata
author_facet Maharana, Prafulla Kumar
Mandal, Sohini
Kaweri, Luci
Sahay, Pranita
Lata, Suman
Asif, Mohamed Ibrahime
Nagpal, Ritu
Sharma, Namrata
author_sort Maharana, Prafulla Kumar
collection PubMed
description The most common cause of corneal graft failure is corneal graft rejection (CGR). Although cornea is one of the immune-privileged sites, it can still get a rejection episode due to a breach in its natural protective mechanism. Both anatomical and structural properties of cornea and anterior chamber contribute toward its immune tolerance. Clinically, every layer of the transplanted cornea can get a rejection episode. A proper understanding of immunopathogenesis will help in understanding the various mechanism of CGR and the development of newer strategies for the prevention and management of such cases.
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spelling pubmed-103913932023-08-02 Immunopathogenesis of corneal graft rejection Maharana, Prafulla Kumar Mandal, Sohini Kaweri, Luci Sahay, Pranita Lata, Suman Asif, Mohamed Ibrahime Nagpal, Ritu Sharma, Namrata Indian J Ophthalmol Review Article The most common cause of corneal graft failure is corneal graft rejection (CGR). Although cornea is one of the immune-privileged sites, it can still get a rejection episode due to a breach in its natural protective mechanism. Both anatomical and structural properties of cornea and anterior chamber contribute toward its immune tolerance. Clinically, every layer of the transplanted cornea can get a rejection episode. A proper understanding of immunopathogenesis will help in understanding the various mechanism of CGR and the development of newer strategies for the prevention and management of such cases. Wolters Kluwer - Medknow 2023-05 2023-05-17 /pmc/articles/PMC10391393/ /pubmed/37203024 http://dx.doi.org/10.4103/IJO.IJO_2866_22 Text en Copyright: © 2023 Indian Journal of Ophthalmology https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Review Article
Maharana, Prafulla Kumar
Mandal, Sohini
Kaweri, Luci
Sahay, Pranita
Lata, Suman
Asif, Mohamed Ibrahime
Nagpal, Ritu
Sharma, Namrata
Immunopathogenesis of corneal graft rejection
title Immunopathogenesis of corneal graft rejection
title_full Immunopathogenesis of corneal graft rejection
title_fullStr Immunopathogenesis of corneal graft rejection
title_full_unstemmed Immunopathogenesis of corneal graft rejection
title_short Immunopathogenesis of corneal graft rejection
title_sort immunopathogenesis of corneal graft rejection
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10391393/
https://www.ncbi.nlm.nih.gov/pubmed/37203024
http://dx.doi.org/10.4103/IJO.IJO_2866_22
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