Cargando…

Cold bandage contact lens use reduces post-photorefractive keratectomy or corneal collagen-crosslinking pain perception in patients

PURPOSE: To compare post-operative pain perception using bandage contact lens (BCL) stored at 2–8°C (Cold BCL, CL-BCL) or room temperature (23 – 25°C, RT-BCL) after photorefractive keratectomy (PRK) or corneal collagen-crosslinking (CXL) and determine status of nociception associated factors. METHOD...

Descripción completa

Detalles Bibliográficos
Autores principales: Shetty, Rohit, Shetty, Naren, Shirodkar, Sailie, Ashok, Nikhil, Sethu, Swaminathan, Ghosh, Arkasubhra, Khamar, Pooja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10391479/
https://www.ncbi.nlm.nih.gov/pubmed/37203044
http://dx.doi.org/10.4103/IJO.IJO_2757_22
_version_ 1785082718422302720
author Shetty, Rohit
Shetty, Naren
Shirodkar, Sailie
Ashok, Nikhil
Sethu, Swaminathan
Ghosh, Arkasubhra
Khamar, Pooja
author_facet Shetty, Rohit
Shetty, Naren
Shirodkar, Sailie
Ashok, Nikhil
Sethu, Swaminathan
Ghosh, Arkasubhra
Khamar, Pooja
author_sort Shetty, Rohit
collection PubMed
description PURPOSE: To compare post-operative pain perception using bandage contact lens (BCL) stored at 2–8°C (Cold BCL, CL-BCL) or room temperature (23 – 25°C, RT-BCL) after photorefractive keratectomy (PRK) or corneal collagen-crosslinking (CXL) and determine status of nociception associated factors. METHODS: In this prospective interventional study, 56 patients undergoing PRK for refractive correction and 100 keratoconus (KC) undergoing CXL were recruited following approval from the institutional ethics committee with informed consent. Patients undergoing bilateral PRK received RT-BCL on one eye and CL-BCL on the other. Pain was graded by Wong–Baker scoring on the first post-operative day (PoD1). Expression of transient receptor potential channels (TRPV1, TRPA1, TRPM8), calcitonin gene-related peptide (CGRP) and IL-6 was measured in cellular content from used BCLs collected on PoD1. Equal number of KC patients received RT-BCL or CL-BCL post-CXL. Pain was graded by Wong–Baker scoring on PoD1. RESULTS: Pain scores on PoD1 were significantly (P < 0.0001) reduced in subjects receiving CL-BCL (Mean ± SD: 2.6 ± 2.1) compared to RT-BCL (6.0 ± 2.4) post-PRK. 80.4% of subjects reported reduced pain scores with CL-BCL. 19.6% reported no change or increased pain scores with CL-BCL. TRPM8 expression was significantly (P < 0.05) increased in BCL of subjects reporting reduced pain with CL-BCL compared to those who did not. Pain scores on PoD1 were significantly (P < 0.0001) reduced in subjects receiving CL-BCL (3.2 ± 2.1) compared to RT-BCL (7.2 ± 1.8) post-CXL. CONCLUSION: The simple approach of using a cold BCL post-operatively substantially reduced pain perception and could overcome post-operative pain-related limited acceptance of PRK/CXL.
format Online
Article
Text
id pubmed-10391479
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Wolters Kluwer - Medknow
record_format MEDLINE/PubMed
spelling pubmed-103914792023-08-02 Cold bandage contact lens use reduces post-photorefractive keratectomy or corneal collagen-crosslinking pain perception in patients Shetty, Rohit Shetty, Naren Shirodkar, Sailie Ashok, Nikhil Sethu, Swaminathan Ghosh, Arkasubhra Khamar, Pooja Indian J Ophthalmol Original Article PURPOSE: To compare post-operative pain perception using bandage contact lens (BCL) stored at 2–8°C (Cold BCL, CL-BCL) or room temperature (23 – 25°C, RT-BCL) after photorefractive keratectomy (PRK) or corneal collagen-crosslinking (CXL) and determine status of nociception associated factors. METHODS: In this prospective interventional study, 56 patients undergoing PRK for refractive correction and 100 keratoconus (KC) undergoing CXL were recruited following approval from the institutional ethics committee with informed consent. Patients undergoing bilateral PRK received RT-BCL on one eye and CL-BCL on the other. Pain was graded by Wong–Baker scoring on the first post-operative day (PoD1). Expression of transient receptor potential channels (TRPV1, TRPA1, TRPM8), calcitonin gene-related peptide (CGRP) and IL-6 was measured in cellular content from used BCLs collected on PoD1. Equal number of KC patients received RT-BCL or CL-BCL post-CXL. Pain was graded by Wong–Baker scoring on PoD1. RESULTS: Pain scores on PoD1 were significantly (P < 0.0001) reduced in subjects receiving CL-BCL (Mean ± SD: 2.6 ± 2.1) compared to RT-BCL (6.0 ± 2.4) post-PRK. 80.4% of subjects reported reduced pain scores with CL-BCL. 19.6% reported no change or increased pain scores with CL-BCL. TRPM8 expression was significantly (P < 0.05) increased in BCL of subjects reporting reduced pain with CL-BCL compared to those who did not. Pain scores on PoD1 were significantly (P < 0.0001) reduced in subjects receiving CL-BCL (3.2 ± 2.1) compared to RT-BCL (7.2 ± 1.8) post-CXL. CONCLUSION: The simple approach of using a cold BCL post-operatively substantially reduced pain perception and could overcome post-operative pain-related limited acceptance of PRK/CXL. Wolters Kluwer - Medknow 2023-05 2023-05-17 /pmc/articles/PMC10391479/ /pubmed/37203044 http://dx.doi.org/10.4103/IJO.IJO_2757_22 Text en Copyright: © 2023 Indian Journal of Ophthalmology https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Shetty, Rohit
Shetty, Naren
Shirodkar, Sailie
Ashok, Nikhil
Sethu, Swaminathan
Ghosh, Arkasubhra
Khamar, Pooja
Cold bandage contact lens use reduces post-photorefractive keratectomy or corneal collagen-crosslinking pain perception in patients
title Cold bandage contact lens use reduces post-photorefractive keratectomy or corneal collagen-crosslinking pain perception in patients
title_full Cold bandage contact lens use reduces post-photorefractive keratectomy or corneal collagen-crosslinking pain perception in patients
title_fullStr Cold bandage contact lens use reduces post-photorefractive keratectomy or corneal collagen-crosslinking pain perception in patients
title_full_unstemmed Cold bandage contact lens use reduces post-photorefractive keratectomy or corneal collagen-crosslinking pain perception in patients
title_short Cold bandage contact lens use reduces post-photorefractive keratectomy or corneal collagen-crosslinking pain perception in patients
title_sort cold bandage contact lens use reduces post-photorefractive keratectomy or corneal collagen-crosslinking pain perception in patients
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10391479/
https://www.ncbi.nlm.nih.gov/pubmed/37203044
http://dx.doi.org/10.4103/IJO.IJO_2757_22
work_keys_str_mv AT shettyrohit coldbandagecontactlensusereducespostphotorefractivekeratectomyorcornealcollagencrosslinkingpainperceptioninpatients
AT shettynaren coldbandagecontactlensusereducespostphotorefractivekeratectomyorcornealcollagencrosslinkingpainperceptioninpatients
AT shirodkarsailie coldbandagecontactlensusereducespostphotorefractivekeratectomyorcornealcollagencrosslinkingpainperceptioninpatients
AT ashoknikhil coldbandagecontactlensusereducespostphotorefractivekeratectomyorcornealcollagencrosslinkingpainperceptioninpatients
AT sethuswaminathan coldbandagecontactlensusereducespostphotorefractivekeratectomyorcornealcollagencrosslinkingpainperceptioninpatients
AT ghosharkasubhra coldbandagecontactlensusereducespostphotorefractivekeratectomyorcornealcollagencrosslinkingpainperceptioninpatients
AT khamarpooja coldbandagecontactlensusereducespostphotorefractivekeratectomyorcornealcollagencrosslinkingpainperceptioninpatients