Photochemical Access to Substituted β-Lactams and β-Lactones via the Zimmerman–O’Connell–Griffin Rearrangement

[Image: see text] A photomediated protocol giving facile access to substituted β-lactam and β-lactones is presented. The method realizes, for the first time, the use of the Zimmerman–O’Connell–Griffin (ZOG) rearrangement in [2 + 2] cycloaddition. Products are obtained in high yield with excellent di...

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Autores principales: Runemark, August, Martos, Mario, Nigríni, Martin, Amombo Noa, Francoise M., Öhrström, Lars, Sundén, Henrik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10391623/
https://www.ncbi.nlm.nih.gov/pubmed/37462268
http://dx.doi.org/10.1021/acs.orglett.3c01990
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author Runemark, August
Martos, Mario
Nigríni, Martin
Amombo Noa, Francoise M.
Öhrström, Lars
Sundén, Henrik
author_facet Runemark, August
Martos, Mario
Nigríni, Martin
Amombo Noa, Francoise M.
Öhrström, Lars
Sundén, Henrik
author_sort Runemark, August
collection PubMed
description [Image: see text] A photomediated protocol giving facile access to substituted β-lactam and β-lactones is presented. The method realizes, for the first time, the use of the Zimmerman–O’Connell–Griffin (ZOG) rearrangement in [2 + 2] cycloaddition. Products are obtained in high yield with excellent diastereoselectivity under visible light irradiation and under mild reaction conditions.
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spelling pubmed-103916232023-08-02 Photochemical Access to Substituted β-Lactams and β-Lactones via the Zimmerman–O’Connell–Griffin Rearrangement Runemark, August Martos, Mario Nigríni, Martin Amombo Noa, Francoise M. Öhrström, Lars Sundén, Henrik Org Lett [Image: see text] A photomediated protocol giving facile access to substituted β-lactam and β-lactones is presented. The method realizes, for the first time, the use of the Zimmerman–O’Connell–Griffin (ZOG) rearrangement in [2 + 2] cycloaddition. Products are obtained in high yield with excellent diastereoselectivity under visible light irradiation and under mild reaction conditions. American Chemical Society 2023-07-18 /pmc/articles/PMC10391623/ /pubmed/37462268 http://dx.doi.org/10.1021/acs.orglett.3c01990 Text en © 2023 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Runemark, August
Martos, Mario
Nigríni, Martin
Amombo Noa, Francoise M.
Öhrström, Lars
Sundén, Henrik
Photochemical Access to Substituted β-Lactams and β-Lactones via the Zimmerman–O’Connell–Griffin Rearrangement
title Photochemical Access to Substituted β-Lactams and β-Lactones via the Zimmerman–O’Connell–Griffin Rearrangement
title_full Photochemical Access to Substituted β-Lactams and β-Lactones via the Zimmerman–O’Connell–Griffin Rearrangement
title_fullStr Photochemical Access to Substituted β-Lactams and β-Lactones via the Zimmerman–O’Connell–Griffin Rearrangement
title_full_unstemmed Photochemical Access to Substituted β-Lactams and β-Lactones via the Zimmerman–O’Connell–Griffin Rearrangement
title_short Photochemical Access to Substituted β-Lactams and β-Lactones via the Zimmerman–O’Connell–Griffin Rearrangement
title_sort photochemical access to substituted β-lactams and β-lactones via the zimmerman–o’connell–griffin rearrangement
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10391623/
https://www.ncbi.nlm.nih.gov/pubmed/37462268
http://dx.doi.org/10.1021/acs.orglett.3c01990
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