Peroxide-Mediated Release of Organophosphates from Boron-Containing Phosphotriesters: A New Class of Organophosphate Prodrugs

[Image: see text] Phosphate mono- and diesters can be liberated efficiently from boryl allyloxy (BAO) and related phosphotriesters by H(2)O(2). This protocol was applied to the release of a phosphorylated serine derivative and the nucleotide analogue AZT monophosphate. Nucleotide release in the pres...

Descripción completa

Detalles Bibliográficos
Autores principales: Klootwyk, Brittany M., Ryan, Amy E., Lopez, Arbil, McCloskey, Mitchell J. R., Janosko, Chasity P., Deiters, Alexander, Floreancig, Paul E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10391626/
https://www.ncbi.nlm.nih.gov/pubmed/37463277
http://dx.doi.org/10.1021/acs.orglett.3c02036

Ejemplares similares

Ejemplares similares