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Straightforward Synthesis of α-Chloromethylketimines Catalyzed by Gold(I). A Clean Way to Building Blocks
[Image: see text] α-Chloromethylketimines have been obtained through a gold-catalyzed hydroamination of aromatic and aliphatic 1-chloroalkynes with aromatic amines by using equimolar amounts of both reagents. This procedure has allowed the preparation and spectroscopic characterization of α-chlorome...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10391627/ https://www.ncbi.nlm.nih.gov/pubmed/35191705 http://dx.doi.org/10.1021/acs.joc.1c02877 |
| _version_ | 1785082753179451392 |
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| author | Sarmiento, Jeymy T. Cárcel, María Ramírez de Arellano, Carmen Varea, Teresa Asensio, Gregorio Olmos, Andrea |
| author_facet | Sarmiento, Jeymy T. Cárcel, María Ramírez de Arellano, Carmen Varea, Teresa Asensio, Gregorio Olmos, Andrea |
| author_sort | Sarmiento, Jeymy T. |
| collection | PubMed |
| description | [Image: see text] α-Chloromethylketimines have been obtained through a gold-catalyzed hydroamination of aromatic and aliphatic 1-chloroalkynes with aromatic amines by using equimolar amounts of both reagents. This procedure has allowed the preparation and spectroscopic characterization of α-chloromethylketimines for the first time with a high degree of purity, complete conversion, and atom economy. The synthetic usefulness of the methodology has been demonstrated with the preparation of β-chloroamines and indoles. |
| format | Online Article Text |
| id | pubmed-10391627 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2022 |
| publisher | American Chemical Society |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-103916272023-08-02 Straightforward Synthesis of α-Chloromethylketimines Catalyzed by Gold(I). A Clean Way to Building Blocks Sarmiento, Jeymy T. Cárcel, María Ramírez de Arellano, Carmen Varea, Teresa Asensio, Gregorio Olmos, Andrea J Org Chem [Image: see text] α-Chloromethylketimines have been obtained through a gold-catalyzed hydroamination of aromatic and aliphatic 1-chloroalkynes with aromatic amines by using equimolar amounts of both reagents. This procedure has allowed the preparation and spectroscopic characterization of α-chloromethylketimines for the first time with a high degree of purity, complete conversion, and atom economy. The synthetic usefulness of the methodology has been demonstrated with the preparation of β-chloroamines and indoles. American Chemical Society 2022-02-22 /pmc/articles/PMC10391627/ /pubmed/35191705 http://dx.doi.org/10.1021/acs.joc.1c02877 Text en © 2022 American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/). |
| spellingShingle | Sarmiento, Jeymy T. Cárcel, María Ramírez de Arellano, Carmen Varea, Teresa Asensio, Gregorio Olmos, Andrea Straightforward Synthesis of α-Chloromethylketimines Catalyzed by Gold(I). A Clean Way to Building Blocks |
| title | Straightforward Synthesis
of α-Chloromethylketimines
Catalyzed by Gold(I). A Clean Way to Building Blocks |
| title_full | Straightforward Synthesis
of α-Chloromethylketimines
Catalyzed by Gold(I). A Clean Way to Building Blocks |
| title_fullStr | Straightforward Synthesis
of α-Chloromethylketimines
Catalyzed by Gold(I). A Clean Way to Building Blocks |
| title_full_unstemmed | Straightforward Synthesis
of α-Chloromethylketimines
Catalyzed by Gold(I). A Clean Way to Building Blocks |
| title_short | Straightforward Synthesis
of α-Chloromethylketimines
Catalyzed by Gold(I). A Clean Way to Building Blocks |
| title_sort | straightforward synthesis
of α-chloromethylketimines
catalyzed by gold(i). a clean way to building blocks |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10391627/ https://www.ncbi.nlm.nih.gov/pubmed/35191705 http://dx.doi.org/10.1021/acs.joc.1c02877 |
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