FOXA2 controls the anti-oxidant response in FH-deficient cells

Hereditary leiomyomatosis and renal cell cancer (HLRCC) is a cancer syndrome caused by inactivating germline mutations in fumarate hydratase (FH) and subsequent accumulation of fumarate. Fumarate accumulation leads to profound epigenetic changes and the activation of an anti-oxidant response via nuc...

Descripción completa

Detalles Bibliográficos
Autores principales: Rogerson, Connor, Sciacovelli, Marco, Maddalena, Lucas A., Pouikli, Andromachi, Segarra-Mondejar, Marc, Valcarcel-Jimenez, Lorea, Schmidt, Christina, Yang, Ming, Ivanova, Elena, Kent, Joshua, Mora, Ariane, Cheeseman, Danya, Carroll, Jason S., Kelsey, Gavin, Frezza, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10391629/
https://www.ncbi.nlm.nih.gov/pubmed/37405921
http://dx.doi.org/10.1016/j.celrep.2023.112751

Ejemplares similares

Ejemplares similares