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Case report: Malignant chemodectoma with hepatic metastasis in a cat
A 10-year-old, male-neutered, domestic short-hair cat was examined at the Veterinary Health Center Emergency Service at Kansas State University for a one-day history of dyspnea. Prior to thoracocentesis, sedation was provided. The cat stopped breathing after sedation and went into cardiac arrest. Ca...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10391646/ https://www.ncbi.nlm.nih.gov/pubmed/37533454 http://dx.doi.org/10.3389/fvets.2023.1216439 |
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author | Adetunji, Shakirat Adeola Chen, Kaiwen Thomason, Justin Matias Ferreyra, Franco |
author_facet | Adetunji, Shakirat Adeola Chen, Kaiwen Thomason, Justin Matias Ferreyra, Franco |
author_sort | Adetunji, Shakirat Adeola |
collection | PubMed |
description | A 10-year-old, male-neutered, domestic short-hair cat was examined at the Veterinary Health Center Emergency Service at Kansas State University for a one-day history of dyspnea. Prior to thoracocentesis, sedation was provided. The cat stopped breathing after sedation and went into cardiac arrest. Cardiopulmonary resuscitation (CPR) was unsuccessful. At necropsy, there was severe pleural effusion and bilateral pulmonary atelectasis. The myocardium of the atria and ventricles, and tunica adventitia of coronary vessels, pulmonary artery, and aorta, had pale, firm, multinodular masses ranging from 0.3 to 0.5 cm in diameter. Multiple nodules were also present in the liver. Multifocally expanding the epicardial fat and compressing the underlying epicardium, infiltrating, and expanding the myocardium, and expanding the walls of major vessels, there was a multinodular, unencapsulated, densely cellular neoplasm composed of polygonal epithelial cells arranged in nests and packets and supported by a fine fibrovascular stroma. The nodules in the liver had similar histologic features. In this case, neoplastic cells at the primary and metastatic sites were intensely immunoreactive to synaptophysin, variably reactive to chromogranin A, and negative for neuron specific enolase, cytokeratin, vimentin, thyroglobulin, and smooth muscle actin. The gross, histologic, and immunohistochemical findings support the diagnosis of chemodectoma, with metastases to the liver. Synaptophysin and chromogranin A were the most useful immunohistochemical markers to diagnose malignant chemodectoma in this cat. |
format | Online Article Text |
id | pubmed-10391646 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-103916462023-08-02 Case report: Malignant chemodectoma with hepatic metastasis in a cat Adetunji, Shakirat Adeola Chen, Kaiwen Thomason, Justin Matias Ferreyra, Franco Front Vet Sci Veterinary Science A 10-year-old, male-neutered, domestic short-hair cat was examined at the Veterinary Health Center Emergency Service at Kansas State University for a one-day history of dyspnea. Prior to thoracocentesis, sedation was provided. The cat stopped breathing after sedation and went into cardiac arrest. Cardiopulmonary resuscitation (CPR) was unsuccessful. At necropsy, there was severe pleural effusion and bilateral pulmonary atelectasis. The myocardium of the atria and ventricles, and tunica adventitia of coronary vessels, pulmonary artery, and aorta, had pale, firm, multinodular masses ranging from 0.3 to 0.5 cm in diameter. Multiple nodules were also present in the liver. Multifocally expanding the epicardial fat and compressing the underlying epicardium, infiltrating, and expanding the myocardium, and expanding the walls of major vessels, there was a multinodular, unencapsulated, densely cellular neoplasm composed of polygonal epithelial cells arranged in nests and packets and supported by a fine fibrovascular stroma. The nodules in the liver had similar histologic features. In this case, neoplastic cells at the primary and metastatic sites were intensely immunoreactive to synaptophysin, variably reactive to chromogranin A, and negative for neuron specific enolase, cytokeratin, vimentin, thyroglobulin, and smooth muscle actin. The gross, histologic, and immunohistochemical findings support the diagnosis of chemodectoma, with metastases to the liver. Synaptophysin and chromogranin A were the most useful immunohistochemical markers to diagnose malignant chemodectoma in this cat. Frontiers Media S.A. 2023-07-18 /pmc/articles/PMC10391646/ /pubmed/37533454 http://dx.doi.org/10.3389/fvets.2023.1216439 Text en Copyright © 2023 Adetunji, Chen, Thomason and Matias Ferreyra. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Veterinary Science Adetunji, Shakirat Adeola Chen, Kaiwen Thomason, Justin Matias Ferreyra, Franco Case report: Malignant chemodectoma with hepatic metastasis in a cat |
title | Case report: Malignant chemodectoma with hepatic metastasis in a cat |
title_full | Case report: Malignant chemodectoma with hepatic metastasis in a cat |
title_fullStr | Case report: Malignant chemodectoma with hepatic metastasis in a cat |
title_full_unstemmed | Case report: Malignant chemodectoma with hepatic metastasis in a cat |
title_short | Case report: Malignant chemodectoma with hepatic metastasis in a cat |
title_sort | case report: malignant chemodectoma with hepatic metastasis in a cat |
topic | Veterinary Science |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10391646/ https://www.ncbi.nlm.nih.gov/pubmed/37533454 http://dx.doi.org/10.3389/fvets.2023.1216439 |
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