Raptor levels are critical for β-cell adaptation to a high-fat diet in male mice

OBJECTIVE: The essential role of raptor/mTORC1 signaling in β-cell survival and insulin processing has been recently demonstrated using raptor knock-out models. Our aim was to evaluate the role of mTORC1 function in adaptation of β-cells to insulin resistant state. METHOD: Here, we use mice with het...

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Detalles Bibliográficos
Autores principales: Blandino-Rosano, Manuel, Louzada, Ruy Andrade, Werneck-De-Castro, Joao Pedro, Lubaczeuski, Camila, Almaça, Joana, Rüegg, Markus A., Hall, Michael N., Leibowitz, Gil, Bernal-Mizrachi, Ernesto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10391668/
https://www.ncbi.nlm.nih.gov/pubmed/37423392
http://dx.doi.org/10.1016/j.molmet.2023.101769

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