Acetylation halts missense mutant p53 aggregation and rescues tumor suppression in non-small cell lung cancers

TP53 mutations are ubiquitous with tumorigenesis in non-small cell lung cancers (NSCLC). By analyzing the TCGA database, we reported that TP53 missense mutations are correlated with chromosomal instability and tumor mutation burden in NSCLC. The inability of wild-type nor mutant p53 expression can&#...

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Detalles Bibliográficos
Autores principales: Xu, Daxing, Qian, Wei, Yang, Zhenkun, Zhang, Zhenhao, Sun, Ping, Wan, Quan, Yin, Ying, Hu, Yaling, Gong, Lingli, Zhang, Bo, Yang, Xusheng, Pu, Zhening, Lu, Peihua, Zou, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10391690/
https://www.ncbi.nlm.nih.gov/pubmed/37534137
http://dx.doi.org/10.1016/j.isci.2023.107003

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