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Metabolomics analysis reveals the differences between Abrus cantoniensis Hance and Abrus mollis Hance

BACKGROUND: Abrus cantoniensis Hance. (Ac) and Abrus mollis (Am), two edible and medicinal plants with economic value in southern China, belong to the Abrus genus. Due to its growth characteristics, Am often replaces Ac in folk medicine. However, the latest National Pharmacopeia of China only recomm...

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Autores principales: Cao, Kexin, Chen, Jianhua, Huang, Rongshao, Lu, Rumei, Zhou, Xiao, Bu, Yuanyuan, Li, Liangbo, Yao, Chun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10391822/
https://www.ncbi.nlm.nih.gov/pubmed/37525109
http://dx.doi.org/10.1186/s12870-023-04372-y
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author Cao, Kexin
Chen, Jianhua
Huang, Rongshao
Lu, Rumei
Zhou, Xiao
Bu, Yuanyuan
Li, Liangbo
Yao, Chun
author_facet Cao, Kexin
Chen, Jianhua
Huang, Rongshao
Lu, Rumei
Zhou, Xiao
Bu, Yuanyuan
Li, Liangbo
Yao, Chun
author_sort Cao, Kexin
collection PubMed
description BACKGROUND: Abrus cantoniensis Hance. (Ac) and Abrus mollis (Am), two edible and medicinal plants with economic value in southern China, belong to the Abrus genus. Due to its growth characteristics, Am often replaces Ac in folk medicine. However, the latest National Pharmacopeia of China only recommends Ac. The differences in the metabolite composition of the plants are directly related to the differences in their clinical efficacy. RESULTS: The difference in metabolites were analyzed using an untargeted metabolomic approach based on ultrahigh-performance liquid chromatography-electrospray ionization-tandem mass spectrometry (UPLC‒ESI‒MS/MS). The roots (R), stems (S) and leaves (L) of the two varieties were examined, and 635 metabolites belonging to 8 classes were detected. A comparative study revealed clear variations in the metabolic profiles of the two plants, and the AmR group had more active ingredients (flavonoids and terpenoids) than the AcR group. The metabolites classified as flavonoids and triterpene saponins showed considerable variations among the various samples. Both Ac and Am had unique metabolites. Two metabolites (isovitexin-2''-xyloside and soyasaponin V) specifically belong to Ac, and nine metabolites (vitexin-2"-O-galactoside, ethyl salicylate, 6-acetamidohexanoic acid, rhein-8-O-glucoside, hederagenin-3-O-glucuronide-28-O-glucosyl(1,2)-glucoside, methyl dioxindole-3-acetate, veratric acid, isorhamnetin-3-O-sophoroside-7-O-rhamnoside, and isorhamnetin-3-O-sophoroside) specifically belong to Am. CONCLUSIONS: The metabolite differences between Ac and Am cause the differences in their clinical efficacy. Our findings serve as a foundation for further investigation of biosynthesis pathways and associated bioactivities and provide guidance for the clinical application of traditional Chinese medicine. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12870-023-04372-y.
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spelling pubmed-103918222023-08-02 Metabolomics analysis reveals the differences between Abrus cantoniensis Hance and Abrus mollis Hance Cao, Kexin Chen, Jianhua Huang, Rongshao Lu, Rumei Zhou, Xiao Bu, Yuanyuan Li, Liangbo Yao, Chun BMC Plant Biol Research BACKGROUND: Abrus cantoniensis Hance. (Ac) and Abrus mollis (Am), two edible and medicinal plants with economic value in southern China, belong to the Abrus genus. Due to its growth characteristics, Am often replaces Ac in folk medicine. However, the latest National Pharmacopeia of China only recommends Ac. The differences in the metabolite composition of the plants are directly related to the differences in their clinical efficacy. RESULTS: The difference in metabolites were analyzed using an untargeted metabolomic approach based on ultrahigh-performance liquid chromatography-electrospray ionization-tandem mass spectrometry (UPLC‒ESI‒MS/MS). The roots (R), stems (S) and leaves (L) of the two varieties were examined, and 635 metabolites belonging to 8 classes were detected. A comparative study revealed clear variations in the metabolic profiles of the two plants, and the AmR group had more active ingredients (flavonoids and terpenoids) than the AcR group. The metabolites classified as flavonoids and triterpene saponins showed considerable variations among the various samples. Both Ac and Am had unique metabolites. Two metabolites (isovitexin-2''-xyloside and soyasaponin V) specifically belong to Ac, and nine metabolites (vitexin-2"-O-galactoside, ethyl salicylate, 6-acetamidohexanoic acid, rhein-8-O-glucoside, hederagenin-3-O-glucuronide-28-O-glucosyl(1,2)-glucoside, methyl dioxindole-3-acetate, veratric acid, isorhamnetin-3-O-sophoroside-7-O-rhamnoside, and isorhamnetin-3-O-sophoroside) specifically belong to Am. CONCLUSIONS: The metabolite differences between Ac and Am cause the differences in their clinical efficacy. Our findings serve as a foundation for further investigation of biosynthesis pathways and associated bioactivities and provide guidance for the clinical application of traditional Chinese medicine. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12870-023-04372-y. BioMed Central 2023-08-01 /pmc/articles/PMC10391822/ /pubmed/37525109 http://dx.doi.org/10.1186/s12870-023-04372-y Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Cao, Kexin
Chen, Jianhua
Huang, Rongshao
Lu, Rumei
Zhou, Xiao
Bu, Yuanyuan
Li, Liangbo
Yao, Chun
Metabolomics analysis reveals the differences between Abrus cantoniensis Hance and Abrus mollis Hance
title Metabolomics analysis reveals the differences between Abrus cantoniensis Hance and Abrus mollis Hance
title_full Metabolomics analysis reveals the differences between Abrus cantoniensis Hance and Abrus mollis Hance
title_fullStr Metabolomics analysis reveals the differences between Abrus cantoniensis Hance and Abrus mollis Hance
title_full_unstemmed Metabolomics analysis reveals the differences between Abrus cantoniensis Hance and Abrus mollis Hance
title_short Metabolomics analysis reveals the differences between Abrus cantoniensis Hance and Abrus mollis Hance
title_sort metabolomics analysis reveals the differences between abrus cantoniensis hance and abrus mollis hance
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10391822/
https://www.ncbi.nlm.nih.gov/pubmed/37525109
http://dx.doi.org/10.1186/s12870-023-04372-y
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