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Assessing Tissue Transmission of Hepatitis C Virus From Viremic Donor to Seronegative Kidney Transplant Recipients: A Case Series

The transmission of hepatitis C virus from viremic donors to seronegative recipients of kidney transplantation is well documented. Pre-transplant administration of direct-acting antivirals prevents viremia, but the seroconversion rate is high. We studied the transmission of the virus through the tra...

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Autores principales: Franco, Antonio, Gosalvez, Carla, Gimeno, Adelina, Trigueros, Migul, Balibrea, Noelia, Perez Contreras, Francisco Javier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10391827/
https://www.ncbi.nlm.nih.gov/pubmed/37534060
http://dx.doi.org/10.3389/ti.2023.11110
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author Franco, Antonio
Gosalvez, Carla
Gimeno, Adelina
Trigueros, Migul
Balibrea, Noelia
Perez Contreras, Francisco Javier
author_facet Franco, Antonio
Gosalvez, Carla
Gimeno, Adelina
Trigueros, Migul
Balibrea, Noelia
Perez Contreras, Francisco Javier
author_sort Franco, Antonio
collection PubMed
description The transmission of hepatitis C virus from viremic donors to seronegative recipients of kidney transplantation is well documented. Pre-transplant administration of direct-acting antivirals prevents viremia, but the seroconversion rate is high. We studied the transmission of the virus through the transplanted tissue by determining viral RNA in 15 kidneys from 8 deceased viremic donors, 5 males and 3 females aged 52.3 ± 15 years. HIV positive donors and active intravenous drugs abusers were discarded to avoid possible window periods in the virus transmission. Recipients, 9 males and 6 females aged 52.7 ± 18 years, were treated with glecaprevir/pibrentasvir for 8 weeks and received immunosuppression with thymoglobulin, tacrolimus, sirolimus and prednisone. Hepatitis C Virus was detected in 9 of the 15 histological samples analyzed but viremia was detected in no recipient at day 1 and 7 post–transplantation and 12 weeks after the treatment. However, 13 of the 15 recipients had seroconverted within 1 month. In conclusion, Hepatitis C virus was detected in a significant proportion of tissue of kidney grafts from viremic donors, but treatment with direct-acting antivirals avoids the transmission of the virus from donor to recipient. Then Donor pools should be expanded.
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spelling pubmed-103918272023-08-02 Assessing Tissue Transmission of Hepatitis C Virus From Viremic Donor to Seronegative Kidney Transplant Recipients: A Case Series Franco, Antonio Gosalvez, Carla Gimeno, Adelina Trigueros, Migul Balibrea, Noelia Perez Contreras, Francisco Javier Transpl Int Health Archive The transmission of hepatitis C virus from viremic donors to seronegative recipients of kidney transplantation is well documented. Pre-transplant administration of direct-acting antivirals prevents viremia, but the seroconversion rate is high. We studied the transmission of the virus through the transplanted tissue by determining viral RNA in 15 kidneys from 8 deceased viremic donors, 5 males and 3 females aged 52.3 ± 15 years. HIV positive donors and active intravenous drugs abusers were discarded to avoid possible window periods in the virus transmission. Recipients, 9 males and 6 females aged 52.7 ± 18 years, were treated with glecaprevir/pibrentasvir for 8 weeks and received immunosuppression with thymoglobulin, tacrolimus, sirolimus and prednisone. Hepatitis C Virus was detected in 9 of the 15 histological samples analyzed but viremia was detected in no recipient at day 1 and 7 post–transplantation and 12 weeks after the treatment. However, 13 of the 15 recipients had seroconverted within 1 month. In conclusion, Hepatitis C virus was detected in a significant proportion of tissue of kidney grafts from viremic donors, but treatment with direct-acting antivirals avoids the transmission of the virus from donor to recipient. Then Donor pools should be expanded. Frontiers Media S.A. 2023-07-05 /pmc/articles/PMC10391827/ /pubmed/37534060 http://dx.doi.org/10.3389/ti.2023.11110 Text en Copyright © 2023 Franco, Gosalvez, Gimeno, Trigueros, Balibrea and Perez Contreras. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Health Archive
Franco, Antonio
Gosalvez, Carla
Gimeno, Adelina
Trigueros, Migul
Balibrea, Noelia
Perez Contreras, Francisco Javier
Assessing Tissue Transmission of Hepatitis C Virus From Viremic Donor to Seronegative Kidney Transplant Recipients: A Case Series
title Assessing Tissue Transmission of Hepatitis C Virus From Viremic Donor to Seronegative Kidney Transplant Recipients: A Case Series
title_full Assessing Tissue Transmission of Hepatitis C Virus From Viremic Donor to Seronegative Kidney Transplant Recipients: A Case Series
title_fullStr Assessing Tissue Transmission of Hepatitis C Virus From Viremic Donor to Seronegative Kidney Transplant Recipients: A Case Series
title_full_unstemmed Assessing Tissue Transmission of Hepatitis C Virus From Viremic Donor to Seronegative Kidney Transplant Recipients: A Case Series
title_short Assessing Tissue Transmission of Hepatitis C Virus From Viremic Donor to Seronegative Kidney Transplant Recipients: A Case Series
title_sort assessing tissue transmission of hepatitis c virus from viremic donor to seronegative kidney transplant recipients: a case series
topic Health Archive
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10391827/
https://www.ncbi.nlm.nih.gov/pubmed/37534060
http://dx.doi.org/10.3389/ti.2023.11110
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