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Increased cardiac PFK-2 protects against high-fat diet-induced cardiomyopathy and mediates beneficial systemic metabolic effects

A healthy heart adapts to changes in nutrient availability and energy demands. In metabolic diseases like type 2 diabetes (T2D), increased reliance on fatty acids for energy production contributes to mitochondrial dysfunction and cardiomyopathy. A principal regulator of cardiac metabolism is 6-phosp...

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Detalles Bibliográficos
Autores principales:	Mendez Garcia, Maria F., Matsuzaki, Satoshi, Batushansky, Albert, Newhardt, Ryan, Kinter, Caroline, Jin, Yan, Mann, Shivani N., Stout, Michael B., Gu, Haiwei, Chiao, Ying Ann, Kinter, Michael, Humphries, Kenneth M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10391959/ https://www.ncbi.nlm.nih.gov/pubmed/37534142 http://dx.doi.org/10.1016/j.isci.2023.107131

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