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SUMOylation of AnxA6 facilitates EGFR-PKCα complex formation to suppress epithelial cancer growth

BACKGROUND: The Annexin A6 (AnxA6) protein is known to inhibit the epidermal growth factor receptor (EGFR)-extracellular signal regulated kinase (ERK)1/2 signaling upon EGF stimulation. While the biochemical mechanism of AnxA6 inactivating phosphorylation of EGFR and ERK1/2 is not completely explore...

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Detalles Bibliográficos
Autores principales:	Sheng, Zenghua, Cao, Xu, Deng, Ya-nan, Zhao, Xinyu, Liang, Shufang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10391975/ https://www.ncbi.nlm.nih.gov/pubmed/37528485 http://dx.doi.org/10.1186/s12964-023-01217-x

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