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Cannabinoid receptor type 1 (CB(1)R) inhibits hypothalamic leptin signaling via β-arrestin1 in complex with TC-PTP and STAT3

Molecular interactions between anorexigenic leptin and orexigenic endocannabinoids, although of great metabolic significance, are not well understood. We report here that hypothalamic STAT3 signaling in mice, initiated by physiological elevations of leptin, is diminished by agonists of the cannabino...

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Detalles Bibliográficos
Autores principales:	Szanda, Gergő, Jourdan, Tony, Wisniewski, Éva, Cinar, Resat, Godlewski, Grzegorz, Rajki, Anikó, Liu, Jie, Chedester, Lee, Szalai, Bence, Tóth, András Dávid, Soltész-Katona, Eszter, Hunyady, László, Inoue, Asuka, Horváth, Viktória Bea, Spät, András, Tam, Joseph, Kunos, George
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10392084/ https://www.ncbi.nlm.nih.gov/pubmed/37534180 http://dx.doi.org/10.1016/j.isci.2023.107207

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