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Synergistic efficacy of PI3Kδ inhibitor with anti-PD-1 mAbs in immune-humanized PDX model of endocrine resistance hormone receptor-positive advanced breast cancer

PURPOSE: Endocrine resistance hormone receptor-positive (HR+) advanced breast cancer (ABC) is generally insensitive to immunecheckpoint inhibitors (ICIs). This study sought to determine whether PI3Kδ inhibitor could enhance the sensitivity of endocrine resistance HR + advanced BC to ICIs by reducing...

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Detalles Bibliográficos
Autores principales:	Li, Yingjue, Li, Yiwen, Yang, Yu, Deng, Yuwei, Ni, Xiangdong, Zhao, Bochen, Yan, Zhaoqi, He, Wen, Li, Yixin, Li, Shuhui, Liu, Linbo, Lu, Dan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10392091/ https://www.ncbi.nlm.nih.gov/pubmed/37533997 http://dx.doi.org/10.1016/j.heliyon.2023.e18498

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