Pretreated EGFR(del19)/BRAF(V600E) Lung Adenocarcinoma With Leptomeningeal Disease Achieving Long-Lasting Disease Control on Osimertinib, Dabrafenib, and Trametinib: A Case Report

Oncogene-addicted NSCLC inevitably becomes resistant to targeted therapy by developing acquired resistance through on- or off-target mechanisms, potentially detectable by liquid biopsy. We present the first reported case of a patient with pretreated EGFR(del19)/BRAF(V600E) lung adenocarcinoma and sy...

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Autores principales: Orciuolo, Corrado, Cappuzzo, Federico, Landi, Lorenza, Resuli, Blerina, Carpano, Silvia, Vidiri, Antonello, Buglioni, Simonetta, Mandoj, Chiara, Ciliberto, Gennaro, Minuti, Gabriele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10392131/
https://www.ncbi.nlm.nih.gov/pubmed/37533438
http://dx.doi.org/10.1016/j.jtocrr.2023.100545
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author Orciuolo, Corrado
Cappuzzo, Federico
Landi, Lorenza
Resuli, Blerina
Carpano, Silvia
Vidiri, Antonello
Buglioni, Simonetta
Mandoj, Chiara
Ciliberto, Gennaro
Minuti, Gabriele
author_facet Orciuolo, Corrado
Cappuzzo, Federico
Landi, Lorenza
Resuli, Blerina
Carpano, Silvia
Vidiri, Antonello
Buglioni, Simonetta
Mandoj, Chiara
Ciliberto, Gennaro
Minuti, Gabriele
author_sort Orciuolo, Corrado
collection PubMed
description Oncogene-addicted NSCLC inevitably becomes resistant to targeted therapy by developing acquired resistance through on- or off-target mechanisms, potentially detectable by liquid biopsy. We present the first reported case of a patient with pretreated EGFR(del19)/BRAF(V600E) lung adenocarcinoma and symptomatic leptomeningeal metastasis obtaining durable clinical benefit on osimertinib, dabrafenib, and trametinib treatment.
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spelling pubmed-103921312023-08-02 Pretreated EGFR(del19)/BRAF(V600E) Lung Adenocarcinoma With Leptomeningeal Disease Achieving Long-Lasting Disease Control on Osimertinib, Dabrafenib, and Trametinib: A Case Report Orciuolo, Corrado Cappuzzo, Federico Landi, Lorenza Resuli, Blerina Carpano, Silvia Vidiri, Antonello Buglioni, Simonetta Mandoj, Chiara Ciliberto, Gennaro Minuti, Gabriele JTO Clin Res Rep Case Report Oncogene-addicted NSCLC inevitably becomes resistant to targeted therapy by developing acquired resistance through on- or off-target mechanisms, potentially detectable by liquid biopsy. We present the first reported case of a patient with pretreated EGFR(del19)/BRAF(V600E) lung adenocarcinoma and symptomatic leptomeningeal metastasis obtaining durable clinical benefit on osimertinib, dabrafenib, and trametinib treatment. Elsevier 2023-06-30 /pmc/articles/PMC10392131/ /pubmed/37533438 http://dx.doi.org/10.1016/j.jtocrr.2023.100545 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Orciuolo, Corrado
Cappuzzo, Federico
Landi, Lorenza
Resuli, Blerina
Carpano, Silvia
Vidiri, Antonello
Buglioni, Simonetta
Mandoj, Chiara
Ciliberto, Gennaro
Minuti, Gabriele
Pretreated EGFR(del19)/BRAF(V600E) Lung Adenocarcinoma With Leptomeningeal Disease Achieving Long-Lasting Disease Control on Osimertinib, Dabrafenib, and Trametinib: A Case Report
title Pretreated EGFR(del19)/BRAF(V600E) Lung Adenocarcinoma With Leptomeningeal Disease Achieving Long-Lasting Disease Control on Osimertinib, Dabrafenib, and Trametinib: A Case Report
title_full Pretreated EGFR(del19)/BRAF(V600E) Lung Adenocarcinoma With Leptomeningeal Disease Achieving Long-Lasting Disease Control on Osimertinib, Dabrafenib, and Trametinib: A Case Report
title_fullStr Pretreated EGFR(del19)/BRAF(V600E) Lung Adenocarcinoma With Leptomeningeal Disease Achieving Long-Lasting Disease Control on Osimertinib, Dabrafenib, and Trametinib: A Case Report
title_full_unstemmed Pretreated EGFR(del19)/BRAF(V600E) Lung Adenocarcinoma With Leptomeningeal Disease Achieving Long-Lasting Disease Control on Osimertinib, Dabrafenib, and Trametinib: A Case Report
title_short Pretreated EGFR(del19)/BRAF(V600E) Lung Adenocarcinoma With Leptomeningeal Disease Achieving Long-Lasting Disease Control on Osimertinib, Dabrafenib, and Trametinib: A Case Report
title_sort pretreated egfr(del19)/braf(v600e) lung adenocarcinoma with leptomeningeal disease achieving long-lasting disease control on osimertinib, dabrafenib, and trametinib: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10392131/
https://www.ncbi.nlm.nih.gov/pubmed/37533438
http://dx.doi.org/10.1016/j.jtocrr.2023.100545
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