Trophoblast cell surface antigen-2 phosphorylation triggered by binding of galectin-3 drives metastasis through down-regulation of E-cadherin

The expression of trophoblast cell surface antigen-2 (Trop-2) is enhanced in many tumor tissues and is correlated with increased malignancy and poor survival of patients with cancer. Previously, we demonstrated that the Ser-322 residue of Trop-2 is phosphorylated by protein kinase Cα (PKCα) and PKCδ...

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Detalles Bibliográficos
Autores principales: Iwamoto, Shungo, Mori, Yugo, Yamashita, Tomoko, Ojima, Kazuki, Akita, Kaoru, Togano, Shingo, Kushiyama, Shuhei, Yashiro, Masakazu, Yatera, Yuki, Yamaguchi, Tomoko, Komiyama, Akane, Sago, Yuki, Itano, Naoki, Nakada, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10392139/
https://www.ncbi.nlm.nih.gov/pubmed/37380081
http://dx.doi.org/10.1016/j.jbc.2023.104971

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