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Host genetic polymorphisms involved in long-term symptoms of COVID-19

Host genetic polymorphisms are recognized as a critical determinant of diversity in clinical symptoms of Coronavirus disease 2019 (COVID-19). Accordingly, this study aimed to determine possible associations between single nucleotide polymorphisms (SNPs) in 37 candidate genetic variants and clinical...

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Autores principales: Udomsinprasert, Wanvisa, Nontawong, Nuttakant, Saengsiwaritt, Wacharapol, Panthan, Bhakbhoom, Jiaranai, Poramate, Thongchompoo, Nartthawee, Santon, Siwalee, Runcharoen, Chakkaphan, Sensorn, Insee, Jittikoon, Jiraphun, Chaikledkaew, Usa, Chantratita, Wasun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10392286/
https://www.ncbi.nlm.nih.gov/pubmed/37497655
http://dx.doi.org/10.1080/22221751.2023.2239952
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author Udomsinprasert, Wanvisa
Nontawong, Nuttakant
Saengsiwaritt, Wacharapol
Panthan, Bhakbhoom
Jiaranai, Poramate
Thongchompoo, Nartthawee
Santon, Siwalee
Runcharoen, Chakkaphan
Sensorn, Insee
Jittikoon, Jiraphun
Chaikledkaew, Usa
Chantratita, Wasun
author_facet Udomsinprasert, Wanvisa
Nontawong, Nuttakant
Saengsiwaritt, Wacharapol
Panthan, Bhakbhoom
Jiaranai, Poramate
Thongchompoo, Nartthawee
Santon, Siwalee
Runcharoen, Chakkaphan
Sensorn, Insee
Jittikoon, Jiraphun
Chaikledkaew, Usa
Chantratita, Wasun
author_sort Udomsinprasert, Wanvisa
collection PubMed
description Host genetic polymorphisms are recognized as a critical determinant of diversity in clinical symptoms of Coronavirus disease 2019 (COVID-19). Accordingly, this study aimed to determine possible associations between single nucleotide polymorphisms (SNPs) in 37 candidate genetic variants and clinical consequences of COVID-19 – especially long-term symptoms, Long COVID. A total of 260 COVID-19 patients, divided into mild (n = 239) and severe (n = 21) and further categorized based on the presence of Long COVID (no, n = 211; yes, n = 49), were recruited. Genotyping of selected polymorphisms responsible for viral entry, immune response, and inflammation was performed using MassARRAY system. Out of 37 SNPs, 9 including leucine zipper transcription factor like-1 (LZTFL1) rs10490770 C allele, LZTFL1 rs11385942 dupA allele, nicotinamide adenine dinucleotide synthetase-1 (NADSYN1) rs12785878 TT genotype, plexin A-4 (PLXNA4) rs1424597 AA genotype, LZTFL1 rs17713054 A allele, interleukin-10 (IL10) rs1800896 TC genotype and C allele, angiotensin converting enzyme-2 (ACE2) rs2285666 T allele, and plasmanylethanolamine desaturase-1 (PEDS1) rs6020298 GG genotype and G allele were significantly associated with an increased risk of developing Long COVID, whereas interleukin-10 receptor subunit beta (IL10RB) rs8178562 GG genotype was significantly associated with a reduced risk of Long COVID. Kaplan-Meier curve displayed that the above gene polymorphisms were significantly associated with cumulative rate of Long COVID occurrence. Polymorphisms in LZTFL1 rs10490770, LZTFL1 rs11385942, LZTFL1 rs17713054, NADSYN1 rs12785878, PLXNA4 rs1424597, IL10 rs1800896, ACE2 rs2285666, PEDS1 rs6020298, and IL10RB rs8178562 appear to be genetic factors involved in development of Long COVID.
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spelling pubmed-103922862023-08-02 Host genetic polymorphisms involved in long-term symptoms of COVID-19 Udomsinprasert, Wanvisa Nontawong, Nuttakant Saengsiwaritt, Wacharapol Panthan, Bhakbhoom Jiaranai, Poramate Thongchompoo, Nartthawee Santon, Siwalee Runcharoen, Chakkaphan Sensorn, Insee Jittikoon, Jiraphun Chaikledkaew, Usa Chantratita, Wasun Emerg Microbes Infect Coronaviruses Host genetic polymorphisms are recognized as a critical determinant of diversity in clinical symptoms of Coronavirus disease 2019 (COVID-19). Accordingly, this study aimed to determine possible associations between single nucleotide polymorphisms (SNPs) in 37 candidate genetic variants and clinical consequences of COVID-19 – especially long-term symptoms, Long COVID. A total of 260 COVID-19 patients, divided into mild (n = 239) and severe (n = 21) and further categorized based on the presence of Long COVID (no, n = 211; yes, n = 49), were recruited. Genotyping of selected polymorphisms responsible for viral entry, immune response, and inflammation was performed using MassARRAY system. Out of 37 SNPs, 9 including leucine zipper transcription factor like-1 (LZTFL1) rs10490770 C allele, LZTFL1 rs11385942 dupA allele, nicotinamide adenine dinucleotide synthetase-1 (NADSYN1) rs12785878 TT genotype, plexin A-4 (PLXNA4) rs1424597 AA genotype, LZTFL1 rs17713054 A allele, interleukin-10 (IL10) rs1800896 TC genotype and C allele, angiotensin converting enzyme-2 (ACE2) rs2285666 T allele, and plasmanylethanolamine desaturase-1 (PEDS1) rs6020298 GG genotype and G allele were significantly associated with an increased risk of developing Long COVID, whereas interleukin-10 receptor subunit beta (IL10RB) rs8178562 GG genotype was significantly associated with a reduced risk of Long COVID. Kaplan-Meier curve displayed that the above gene polymorphisms were significantly associated with cumulative rate of Long COVID occurrence. Polymorphisms in LZTFL1 rs10490770, LZTFL1 rs11385942, LZTFL1 rs17713054, NADSYN1 rs12785878, PLXNA4 rs1424597, IL10 rs1800896, ACE2 rs2285666, PEDS1 rs6020298, and IL10RB rs8178562 appear to be genetic factors involved in development of Long COVID. Taylor & Francis 2023-07-31 /pmc/articles/PMC10392286/ /pubmed/37497655 http://dx.doi.org/10.1080/22221751.2023.2239952 Text en © 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group, on behalf of Shanghai Shangyixun Cultural Communication Co., Ltd https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.
spellingShingle Coronaviruses
Udomsinprasert, Wanvisa
Nontawong, Nuttakant
Saengsiwaritt, Wacharapol
Panthan, Bhakbhoom
Jiaranai, Poramate
Thongchompoo, Nartthawee
Santon, Siwalee
Runcharoen, Chakkaphan
Sensorn, Insee
Jittikoon, Jiraphun
Chaikledkaew, Usa
Chantratita, Wasun
Host genetic polymorphisms involved in long-term symptoms of COVID-19
title Host genetic polymorphisms involved in long-term symptoms of COVID-19
title_full Host genetic polymorphisms involved in long-term symptoms of COVID-19
title_fullStr Host genetic polymorphisms involved in long-term symptoms of COVID-19
title_full_unstemmed Host genetic polymorphisms involved in long-term symptoms of COVID-19
title_short Host genetic polymorphisms involved in long-term symptoms of COVID-19
title_sort host genetic polymorphisms involved in long-term symptoms of covid-19
topic Coronaviruses
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10392286/
https://www.ncbi.nlm.nih.gov/pubmed/37497655
http://dx.doi.org/10.1080/22221751.2023.2239952
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