A Case Report and Literature Review of the Role of Dupilumab in the Management of Lichen Planus: Cause or Treatment?

Lichen planus (LP) is a chronic inflammatory skin condition characterized by the six Ps (ie. purple, planar, polygonal, pruritic, plaques, and papules) often causing physical, emotional, and psychological stress for the person affected. Drug-induced LP has been described after the administration of...

Descripción completa

Detalles Bibliográficos
Autores principales: Gajraj, Farrah A, Zahir, Jamal, Adereti, Christopher, Gajraj, Mohamed H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Dermatology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10392291/
https://www.ncbi.nlm.nih.gov/pubmed/37533618
http://dx.doi.org/10.7759/cureus.41274
_version_ 1785082923435687936
author Gajraj, Farrah A
Zahir, Jamal
Adereti, Christopher
Gajraj, Mohamed H
author_facet Gajraj, Farrah A
Zahir, Jamal
Adereti, Christopher
Gajraj, Mohamed H
author_sort Gajraj, Farrah A
collection PubMed
description Lichen planus (LP) is a chronic inflammatory skin condition characterized by the six Ps (ie. purple, planar, polygonal, pruritic, plaques, and papules) often causing physical, emotional, and psychological stress for the person affected. Drug-induced LP has been described after the administration of drugs like antihypertensives, non-steroidal anti-inflammatory drugs (NSAIDs), and biologics like adalimumab and etanercept. Currently, there is a dearth of studies discussing the association between LP and dupilumab. Here, we present the case of a young adult female who developed LP 24 months after treatment with dupilumab for severe atopic dermatitis. We also conducted a review of the literature discussing the association between LP and dupilumab.
format Online
Article
Text
id pubmed-10392291
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Cureus
record_format MEDLINE/PubMed
spelling pubmed-103922912023-08-02 A Case Report and Literature Review of the Role of Dupilumab in the Management of Lichen Planus: Cause or Treatment? Gajraj, Farrah A Zahir, Jamal Adereti, Christopher Gajraj, Mohamed H Cureus Dermatology Lichen planus (LP) is a chronic inflammatory skin condition characterized by the six Ps (ie. purple, planar, polygonal, pruritic, plaques, and papules) often causing physical, emotional, and psychological stress for the person affected. Drug-induced LP has been described after the administration of drugs like antihypertensives, non-steroidal anti-inflammatory drugs (NSAIDs), and biologics like adalimumab and etanercept. Currently, there is a dearth of studies discussing the association between LP and dupilumab. Here, we present the case of a young adult female who developed LP 24 months after treatment with dupilumab for severe atopic dermatitis. We also conducted a review of the literature discussing the association between LP and dupilumab. Cureus 2023-07-02 /pmc/articles/PMC10392291/ /pubmed/37533618 http://dx.doi.org/10.7759/cureus.41274 Text en Copyright © 2023, Gajraj et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Dermatology
Gajraj, Farrah A
Zahir, Jamal
Adereti, Christopher
Gajraj, Mohamed H
A Case Report and Literature Review of the Role of Dupilumab in the Management of Lichen Planus: Cause or Treatment?
title A Case Report and Literature Review of the Role of Dupilumab in the Management of Lichen Planus: Cause or Treatment?
title_full A Case Report and Literature Review of the Role of Dupilumab in the Management of Lichen Planus: Cause or Treatment?
title_fullStr A Case Report and Literature Review of the Role of Dupilumab in the Management of Lichen Planus: Cause or Treatment?
title_full_unstemmed A Case Report and Literature Review of the Role of Dupilumab in the Management of Lichen Planus: Cause or Treatment?
title_short A Case Report and Literature Review of the Role of Dupilumab in the Management of Lichen Planus: Cause or Treatment?
title_sort case report and literature review of the role of dupilumab in the management of lichen planus: cause or treatment?
topic Dermatology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10392291/
https://www.ncbi.nlm.nih.gov/pubmed/37533618
http://dx.doi.org/10.7759/cureus.41274
work_keys_str_mv AT gajrajfarraha acasereportandliteraturereviewoftheroleofdupilumabinthemanagementoflichenplanuscauseortreatment
AT zahirjamal acasereportandliteraturereviewoftheroleofdupilumabinthemanagementoflichenplanuscauseortreatment
AT aderetichristopher acasereportandliteraturereviewoftheroleofdupilumabinthemanagementoflichenplanuscauseortreatment
AT gajrajmohamedh acasereportandliteraturereviewoftheroleofdupilumabinthemanagementoflichenplanuscauseortreatment
AT gajrajfarraha casereportandliteraturereviewoftheroleofdupilumabinthemanagementoflichenplanuscauseortreatment
AT zahirjamal casereportandliteraturereviewoftheroleofdupilumabinthemanagementoflichenplanuscauseortreatment
AT aderetichristopher casereportandliteraturereviewoftheroleofdupilumabinthemanagementoflichenplanuscauseortreatment
AT gajrajmohamedh casereportandliteraturereviewoftheroleofdupilumabinthemanagementoflichenplanuscauseortreatment

Ejemplares similares