The conformational plasticity of the selectivity filter methionines controls the in-cell Cu(I) uptake through the CTR1 transporter

Copper is a trace element vital to many cellular functions. Yet its abnormal levels are toxic to cells, provoking a variety of severe diseases. The high affinity copper transporter 1 (CTR1), being the main in-cell copper [Cu(I)] entry route, tightly regulates its cellular uptake via a still elusive...

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Detalles Bibliográficos
Autores principales: Janoš, Pavel, Aupič, Jana, Ruthstein, Sharon, Magistrato, Alessandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10392627/
https://www.ncbi.nlm.nih.gov/pubmed/37529280
http://dx.doi.org/10.1017/qrd.2022.2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10392627/
https://www.ncbi.nlm.nih.gov/pubmed/37529280
http://dx.doi.org/10.1017/qrd.2022.2

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