The G protein-first activation mechanism of opioid receptors by Gi protein and agonists

We report the G protein-first mechanism for activation of G protein-coupled receptors (GPCR) for the three closest subtypes of the opioid receptors (OR), μOR, κOR and δOR. We find that they couple to the inactive Gi protein-bound guanosine diphosphate (GDP) prior to agonist binding. The inactive Gi...

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Detalles Bibliográficos
Autores principales: Mafi, Amirhossein, Kim, Soo-Kyung, Goddard, William A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10392629/
https://www.ncbi.nlm.nih.gov/pubmed/37529677
http://dx.doi.org/10.1017/qrd.2021.7

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